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Study Information
Study Attribute Value
CEBS Accession Number: 002-02762-0001-0000-0
Chemical Name: Quercetin
CASRN: 117-39-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 305922_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 10/28/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 410 0.390 8.20 25.8 0.000
Test Chemical Quercetin 
 0.67      
 50 1044 1041 0.997 20.82 25.8 155.362 
2         
 50 1046 563 0.538 11.26 25.8 37.842 
6.7       
 5 104 92 0.885 18.40 25.8 126.548 
20         
 50 1046 1087 1.039 21.74 25.8 166.136 
66.7       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1044 663 0.635 13.26 25.8 62.637
Mitomycin-C 
 0.01      
 5 105 181 1.724 36.20 25.8 341.463
Trend: 13.459        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/28/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1043 404 0.387 8.08 25.8 0.000
Test Chemical Quercetin 
2         
 50 1048 506 0.483 10.12 25.8 24.650 
6.7       
 50 1043 587 0.563 11.74 25.8 45.297 
20         
 50 1041 597 0.573 11.94 25.8 48.056 
66.7       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1048 613 0.585 12.26 25.8 51.009
Cyclophosphamide 
2         
 5 104 169 1.625 33.80 25.8 319.524
Trend: 6.543        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 11/20/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 25 522 180 0.345 7.20 25.3 0.000
Test Chemical Quercetin 
20         
 25 524 272 0.519 10.88 25.3 50.534 
30         
 25 524 308 0.588 12.32 25.3 70.458 
45         
 25 522 414 0.793 16.56 25.3 130.000 
60         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 25 521 323 0.620 12.92 25.3 79.789
Cyclophosphamide 
2         
 5 103 230 2.233 46.00 25.3 547.573
Trend: 9.631        
Probability: 0.000