COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-02762-0002-0000-1
Chemical Name: Quercetin
CASRN: 117-39-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 305922_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 12/18/1986    Harvest Time: 20.3 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Quercetin 
7.6       
 200 7 0.035 3.5 2 0.010 1.0 2 0.010 1.0 3 0.015 1.5 
10.1       
 200 37 0.185 10.0 9 0.045 4.5 25 0.125 4.5 3 0.015 1.5 
25.2       
 200 102 0.510 21.5 37 0.185 12.5 45 0.225 13.0 20 0.100 1.0
Positive Control: Mitomycin-C 
 0.05      
 200 95 0.475 26.5 43 0.215 16.5 52 0.260 15.5 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 38 1.520 72.0 14 0.560 44.0 24 0.960 60.0 0 0.000 0.0
Trend: 7.645 5.879 6.634  
Probability: 0.000 0.000 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 12/17/1986    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 8 0.040 4.0 2 0.010 1.0 5 0.025 2.5 1 0.005 0.5
Dimethyl Sulfoxide 
0         
 200 5 0.025 2.5 4 0.020 2.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: Quercetin 
25.2       
 20 58 2.900 45.0 1 0.050 5.0 6 0.300 10.0 51 2.550 30.0 
50.3       
 48 27 0.563 33.3 4 0.083 8.3 23 0.479 31.3 0 0.000 0.0 
75         
 25 171 6.840 100.0 3 0.120 8.0 14 0.560 24.0 154 6.160 76.0
Positive Control: Cyclophosphamide 
7.5       
 200 62 0.310 14.5 12 0.060 3.0 50 0.250 12.5 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 42 1.680 56.0 9 0.360 24.0 22 0.880 36.0 11 0.440 8.0
Trend: 11.225 2.362 7.278  
Probability: 0.000 0.009 0.000  


Trial #:2   Activation: No Activation    Date: 01/21/1987    Harvest Time: 19.8 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Quercetin 
25         
 100 19 0.190 7.0 3 0.030 2.0 6 0.060 4.0 10 0.100 1.0 
37.5       
 100 25 0.250 15.0 9 0.090 7.0 16 0.160 9.0 0 0.000 0.0 
50         
 100 42 0.420 29.0 19 0.190 18.0 23 0.230 15.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 100 45 0.450 30.0 18 0.180 15.0 27 0.270 20.0 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 25 1.000 60.0 7 0.280 24.0 18 0.720 48.0 0 0.000 0.0
Trend: 6.047 4.816 4.359  
Probability: 0.000 0.000 0.000