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Study Information
Study Attribute Value
CEBS Accession Number: 002-02766-0001-0000-4
Chemical Name: Quinoline
CASRN: 91-22-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 038247_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Test Failure 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 12/21/1981    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1049 395 0.377 7.90 26.0 -15.581
Dimethyl Sulfoxide 
0         
 50 1038 463 0.446 9.26 26.0 0.000
Test Chemical Quinoline 
16         
 50 1038 471 0.454 9.42 26.0 1.728 
50         
 50 1043 520 0.499 10.40 26.0 11.773 
160         
 50 1039 599 0.577 11.98 26.0 29.249 
500         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.01      
 50 1040 1954 1.879 39.08 26.0 321.219
Trend: 4.478        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 01/08/1982    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1046 447 0.427 8.94 26.0 -0.638
Dimethyl Sulfoxide 
0         
 50 1037 446 0.430 8.92 26.0 0.000
Test Chemical Quinoline 
100         
 50 1036 469 0.453 9.38 26.0 5.258 
200         
 0 0 0 0.000 0.00 26.0 N/A 
300         
 0 0 0 0.000 0.00 26.0 N/A 
400         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.005     
 50 1046 1412 1.350 28.24 26.0 213.868
Trend: 0.775        
Probability: 0.219        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 12/21/1981    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1042 542 0.520 10.84 26.0 -5.958
Dimethyl Sulfoxide 
0         
 50 1045 578 0.553 11.56 26.0 0.000
Test Chemical Quinoline 
 0.5       
 50 1045 625 0.598 12.50 26.0 8.131 
1.6       
 50 1029 668 0.649 13.36 26.0 17.368 
5         
 50 1044 807 0.773 16.14 26.0 39.753 
16         
 50 1052 1376 1.308 27.52 26.0 136.478 
50         
 50 1039 1478 1.423 29.56 26.0 157.186 
160         
 50 1050 1505 1.433 30.10 26.0 159.141
Positive Control Cyclophosphamide 
1.5       
 50 1040 1603 1.541 32.06 26.0 178.669
Trend: 30.782        
Probability: 0.000