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Study Information
Study Attribute Value
CEBS Accession Number: 002-02766-0003-0000-6
Chemical Name: Quinoline
CASRN: 91-22-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 256407_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
No Activation  2  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 02/19/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 467 0.445 9.34 26.5 0.000
Test Chemical Quinoline 
1.6       
 50 1048 387 0.369 7.74 26.5 -17.052 
5         
 50 1049 410 0.391 8.20 26.5 -12.206 
16         
 50 1050 473 0.450 9.46 26.5 1.188 
50         
 50 1049 470 0.448 9.40 26.5 0.642 
160         
 0 0 0 0.000 0.00 26.5 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1051 631 0.600 12.62 26.5 34.861
Mitomycin-C 
 0.005     
 10 210 277 1.319 27.70 26.5 196.291
Trend: 1.375        
Probability: 0.085        

Trial #: 2    Activation: No Activation    Date: 06/11/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 502 0.479 10.04 26.0 0.000
Test Chemical Quinoline 
50         
 50 1046 482 0.461 9.64 31.0 -3.800 
75         
 50 1045 542 0.519 10.84 31.0 8.278 
100         
 50 1044 482 0.462 9.64 31.0 -3.616 
150         
 50 1041 538 0.517 10.76 36.0 7.892 
200         
 0 0 0 0.000 0.00 36.0 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1052 623 0.592 12.46 26.0 23.632
Mitomycin-C 
 0.005     
 10 209 259 1.239 25.90 26.0 158.709
Trend: 1.226        
Probability: 0.110        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/11/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1041 499 0.479 9.98 26.0 0.000
Test Chemical Quinoline 
100         
 50 1050 1043 0.993 20.86 26.0 107.226 
200         
 50 1046 1205 1.152 24.10 26.0 140.329 
400         
 50 1049 1126 1.073 22.52 26.0 123.930 
600         
 7 147 144 0.980 20.57 26.0 104.360 
800         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.2       
 50 1049 980 0.934 19.60 26.0 94.895
Cyclophosphamide 
 0.6       
 10 211 264 1.251 26.40 26.0 161.019
Trend: 13.296        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 08/27/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 439 0.419 8.78 26.0 0.000
Test Chemical Quinoline 
400         
 50 1049 954 0.909 19.08 31.0 116.898 
600         
 50 1049 1052 1.003 21.04 36.0 139.179 
600         
 50 1046 1006 0.962 20.12 31.0 129.376 
800         
 50 1050 1188 1.131 23.76 36.0 169.842
Positive Control Cyclophosphamide 
 0.1       
 50 1048 622 0.594 12.44 26.0 41.550
Cyclophosphamide 
 0.6       
 10 210 297 1.414 29.70 26.0 237.302
Trend: 16.754        
Probability: 0.000