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Study Information
Study Attribute Value
CEBS Accession Number: 002-02766-0004-0000-7
Chemical Name: Quinoline
CASRN: 91-22-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 256407_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #:1   Activation: No Activation    Date: 09/18/1985    Harvest Time: 17 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 6 0.030 3.0 3 0.015 1.5 3 0.015 1.5 0 0.000 0.0
Test Chemical: Quinoline 
160         
 200 7 0.035 3.5 4 0.020 2.0 3 0.015 1.5 0 0.000 0.0 
300         
 200 4 0.020 2.0 1 0.005 0.5 3 0.015 1.5 0 0.000 0.0 
500         
 200 7 0.035 3.5 2 0.010 1.0 5 0.025 2.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 35 0.175 14.5 11 0.055 5.5 24 0.120 9.5 0 0.000 0.0
Mitomycin-C 
 0.125     
 50 22 0.440 36.0 6 0.120 12.0 16 0.320 26.0 0 0.000 0.0
Trend: -0.038 -0.888 0.703  
Probability: 0.515 0.813 0.241  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 09/18/1985    Harvest Time: 18 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Test Chemical: Quinoline 
300         
 200 20 0.100 8.5 14 0.070 6.5 6 0.030 3.0 0 0.000 0.0 
500         
 200 82 0.410 26.0 60 0.300 21.5 22 0.110 9.5 0 0.000 0.0 
750         
 200 526 2.630 85.0 206 1.030 57.5 319 1.595 74.5 1 0.005 1.0 
1000         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 200 334 1.670 78.5 122 0.610 43.0 171 0.855 58.0 41 0.205 5.0
Cyclophosphamide 
10         
 50 109 2.180 88.0 46 0.920 56.0 63 1.260 70.0 0 0.000 0.0
Trend: 18.589 14.267 17.429  
Probability: 0.000 0.000 0.000  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 10/23/1985    Harvest Time: 18 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Quinoline 
160         
 200 9 0.045 4.0 2 0.010 1.0 7 0.035 3.5 0 0.000 0.0 
300         
 200 8 0.040 3.0 3 0.015 1.5 5 0.025 2.0 0 0.000 0.0 
500         
 200 22 0.110 8.5 14 0.070 6.0 8 0.040 4.0 0 0.000 0.0 
750         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 46 0.230 19.5 13 0.065 6.5 33 0.165 14.5 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 54 1.080 60.0 22 0.440 36.0 22 0.440 34.0 10 0.200 1.0
Trend: 3.932 4.009 2.107  
Probability: 0.000 0.000 0.018