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Study Information
Study Attribute Value
CEBS Accession Number: 002-02766-0005-0000-8
Chemical Name: Quinoline
CASRN: 91-22-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 563472_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 11/19/1980    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 393 0.375 7.86 26.0 0.000
Test Chemical Quinoline 
 0.05      
 50 1049 370 0.353 7.40 26.0 -5.942 
 0.5       
 50 1050 374 0.356 7.48 26.0 -5.016 
5         
 50 1047 430 0.411 8.60 26.0 9.519 
50         
 50 1051 436 0.415 8.72 26.0 10.625 
500         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Triethylenemelamine 
 0.025     
 50 1045 2088 1.998 41.76 26.0 432.823
Trend: 2.282        
Probability: 0.011        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 11/19/1980    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 424 0.404 8.48 26.0 0.000
Test Chemical Quinoline 
 0.05      
 50 1047 430 0.411 8.60 26.0 1.609 
 0.5       
 50 1050 420 0.400 8.40 26.0 -1.038 
5         
 50 1047 474 0.453 9.48 26.0 12.006 
50         
 50 1048 782 0.746 15.64 26.0 84.610 
500         
 45 938 809 0.862 17.98 26.0 113.381
Positive Control Cyclophosphamide 
1.5       
 50 1047 1613 1.541 32.26 26.0 281.151
Trend: 17.077        
Probability: 0.000