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Study Information
Study Attribute Value
CEBS Accession Number: 002-02766-0006-0000-9
Chemical Name: Quinoline
CASRN: 91-22-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 563472_CA
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive 

Trial #:1   Activation: No Activation    Date: 11/19/1980    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Quinoline 
 0.05      
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
 0.5       
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
5         
 100 8 0.080 6.0 3 0.030 2.0 5 0.050 5.0 0 0.000 0.0 
50         
 100 4 0.040 2.0 0 0.000 0.0 4 0.040 2.0 0 0.000 0.0 
500         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0
Positive Control: Triethylenemelamine 
 0.25      
 100 57 0.570 42.0 21 0.210 19.0 36 0.360 27.0 0 0.000 0.0
Trend: 1.455 0.169 1.560  
Probability: 0.073 0.433 0.059  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 11/19/1980    Harvest Time: 14 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Quinoline 
 0.05      
 100 6 0.060 4.0 1 0.010 1.0 5 0.050 3.0 0 0.000 0.0 
 0.5       
 100 4 0.040 4.0 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 
5         
 100 5 0.050 5.0 3 0.030 3.0 2 0.020 2.0 0 0.000 0.0 
50         
 100 7 0.070 7.0 3 0.030 3.0 4 0.040 4.0 0 0.000 0.0 
500         
 100 27 0.270 20.0 17 0.170 17.0 10 0.100 9.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
25         
 100 88 0.880 54.0 41 0.410 34.0 47 0.470 33.0 0 0.000 0.0
Trend: 4.684 4.647 3.196  
Probability: 0.000 0.000 0.001