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Study Information
Study Attribute Value
CEBS Accession Number: 002-02766-0007-0000-0
Chemical Name: Quinoline
CASRN: 91-22-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 725295_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Negative 
No Activation  3  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 
Induced Rat Liver S9  3_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 07/19/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1040 340 0.327 6.80 27.0 -12.344
Dimethyl Sulfoxide 
0         
 50 1043 389 0.373 7.78 27.0 0.000
Test Chemical Quinoline 
1.6       
 50 1044 438 0.420 8.76 27.0 12.489 
5         
 50 1037 424 0.409 8.48 27.0 9.628 
16         
 50 1035 403 0.389 8.06 27.0 4.400 
50         
 50 1046 477 0.456 9.54 27.0 22.270 
160         
 50 1039 508 0.489 10.16 27.0 31.094 
500         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.005     
 50 1039 1188 1.143 23.76 27.0 206.574
Mitomycin-C 
 0.01      
 50 1041 1583 1.521 31.66 27.0 307.723
Trend: 3.974        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 08/13/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1040 314 0.302 6.28 26.0 -10.894
Dimethyl Sulfoxide 
0         
 50 1030 349 0.339 6.98 26.0 0.000
Test Chemical Quinoline 
5         
 50 1043 393 0.377 7.86 26.0 11.204 
16         
 50 1040 393 0.378 7.86 26.0 11.525 
50         
 50 1048 401 0.383 8.02 26.0 12.926 
160         
 50 1036 412 0.398 8.24 31.0 17.368 
160         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.005     
 50 1032 1005 0.974 20.10 26.0 187.408
Trend: 1.998        
Probability: 0.023        

Trial #: 3    Activation: No Activation    Date: 09/21/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1043 463 0.444 9.26 26.5 -4.276
Dimethyl Sulfoxide 
0         
 50 1048 486 0.464 9.72 26.5 0.000
Test Chemical Quinoline 
5         
 50 1046 429 0.410 8.58 26.5 -11.560 
16         
 50 1046 408 0.390 8.16 26.5 -15.889 
50         
 50 1041 356 0.342 7.12 26.5 -26.256 
160         
 0 0 0 0.000 0.00 26.5 N/A
Positive Control Mitomycin-C 
 0.005     
 50 1044 1279 1.225 25.58 26.5 164.177
Trend: -4.393        
Probability: 1.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/14/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1036 375 0.362 7.50 27.0 0.000
Negative (Not Specified) 
0         
 50 1029 383 0.372 7.66 27.0 2.828
Test Chemical Quinoline 
16         
 50 1038 452 0.435 9.04 27.0 20.301 
50         
 50 1036 462 0.446 9.24 27.0 23.200 
160         
 50 1030 410 0.398 8.20 27.0 9.970 
500         
 50 1027 499 0.486 9.98 27.0 34.233 
1000         
 0 0 0 0.000 0.00 27.0 N/A
Positive Control Cyclophosphamide 
1.5       
 50 1035 1100 1.063 22.00 27.0 193.617
Trend: 3.234        
Probability: 0.001        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 08/13/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1041 439 0.422 8.78 26.0 0.000
Negative (Not Specified) 
0         
 50 1043 420 0.403 8.40 26.0 -4.511
Test Chemical Quinoline 
100         
 50 1044 606 0.580 12.12 26.0 37.644 
250         
 50 1048 583 0.556 11.66 26.0 31.915 
500         
 50 1040 585 0.563 11.70 26.0 33.386 
750         
 50 1049 619 0.590 12.38 26.0 39.927 
1000         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
1.5       
 50 1048 1533 1.463 30.66 26.0 246.870
Cyclophosphamide 
2         
 50 1049 1868 1.781 37.36 26.0 322.267
Trend: 4.284        
Probability: 0.000        

Trial #: 3_S9    Activation: Induced Rat Liver S9    Date: 09/21/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 477 0.455 9.54 26.0 0.000
Negative (Not Specified) 
0         
 50 1045 484 0.463 9.68 26.0 1.759
Test Chemical Quinoline 
1.6       
 50 1037 526 0.507 10.52 26.0 11.442 
5         
 50 1045 557 0.533 11.14 26.0 17.107 
16         
 50 1040 749 0.720 14.98 26.0 58.231 
50         
 50 1040 802 0.771 16.04 26.0 69.428 
160         
 50 1049 896 0.854 17.92 26.0 87.662 
500         
 50 1044 859 0.823 17.18 26.0 80.774
Positive Control Cyclophosphamide 
2         
 50 1044 2346 2.247 46.92 26.0 393.708
Cyclophosphamide 
2         
 50 1046 2049 1.959 40.98 26.0 330.381
Trend: 15.236        
Probability: 0.000