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Study Information
Study Attribute Value
CEBS Accession Number: 002-02766-0009-0000-2
Chemical Name: Quinoline
CASRN: 91-22-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 760472_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 12/19/1980    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 479 0.456 9.58 27.0 0.000
Negative (Not Specified) 
0         
 50 1038 418 0.403 8.36 27.0 -11.726
Test Chemical Quinoline 
 0.87      
 50 1047 416 0.397 8.32 27.0 -12.904 
4.4       
 50 1043 484 0.464 9.68 27.0 1.722 
22         
 50 1046 421 0.402 8.42 27.0 -11.772 
110         
 50 1029 508 0.494 10.16 31.0 8.219
Positive Control Triethylenemelamine 
 0.015     
 50 1047 2619 2.501 52.38 27.0 448.331
Trend: 1.208        
Probability: 0.113        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 11/06/1980    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1044 450 0.431 9.00 26.5 -1.667
Dimethyl Sulfoxide 
0         
 50 1038 455 0.438 9.10 26.5 0.000
Test Chemical Quinoline 
 0.87      
 50 1025 468 0.457 9.36 26.5 4.162 
4.4       
 50 1028 575 0.559 11.50 26.5 27.603 
22         
 50 1042 718 0.689 14.36 26.5 57.196 
110         
 50 1037 862 0.831 17.24 26.5 89.633 
550         
 50 1002 895 0.893 17.90 26.5 103.770
Positive Control Cyclophosphamide 
1.5       
 50 1037 1512 1.458 30.24 26.5 232.628
Trend: 16.804        
Probability: 0.000