Genetic Toxicology - Mammalian Cell Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-02766-0016-0000-0
Chemical Name:	Quinoline
CASRN:	91-22-5
NTP Study Type:	Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID:	359723
Study Result:	Positive

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Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call:
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Dimethyl Sulfoxide	0	61	91	120	66	63
			69	96	124	60
			59	108	93	53
			64	105	143	75
Test Chemical	Quinoline	62.5	64	94	107	56	64
			60	93	127	71	64
		125	65	78	126	65	68
			68	88	144	71	68
		250	60	84	166	93	89
			58	81	148	85	89
		500	61	73	128	70	65
			80	79	145	60	65
		1000

Positive Control	Methyl Methane Sulfonate	15	37	47	253	230	225*
Positive Control			42	45	275	221	225*

Nonactivation Trial: 2 Experiment Call:
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Dimethyl Sulfoxide	0	55	93	33	20	32
			61	102	69	38
			48r	102	37	26
			63	105	74	39
Test Chemical	Quinoline	100	60	93	50	28	23
			68	105	36	18	23
		300	59	80	67	38	33
			65	79	54	28	33
		500	50	65	70	47	44
			57	66	69	41	44
		700	61	64	60	33	34
			73	55	76	35	34
		900	28	17	95	112	89*
			33	16	65	66	89*
		1100

Positive Control	Methyl Methane Sulfonate	15	51	50	111	72	75*
			41	54	95	77	75*
	Methyl Methane Sulfonate	250	21	22	238	387	278*
			42	57	210	169	278*

Nonactivation Trial: 3 Experiment Call:
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Dimethyl Sulfoxide	0	82	103	96	39	35
			93	105	98	35
			96	105	91	32
			96	87	104	36
Test Chemical	Quinoline	300	96	81	91	32	30
			91	79	79	29	30
		500	106	58	133	42	45
			92	55	134	49	45
		700	98	21	228	78	82*
			105	46	272	86	82*
		800	93	15	362	130	124*
			98	10	351	119	124*
		900

Positive Control	Methyl Methane Sulfonate	15	63	32	244	129	125*
			61	36	224	122	125*
	Methyl Methane Sulfonate	250	61	71	365	201	195*
			73	63	413	189	195*

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination