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Study Information
Study Attribute Value
CEBS Accession Number: 002-02766-0017-0000-1
Chemical Name: Quinoline
CASRN: 91-22-5
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 745521_SCE
Study Result: Negative


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 09/30/85 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 5.51 ± 0.401
Test Chemical Quinoline 
25         
 4 4.30 ± 0.863
  
50         
 4 3.51 ± 0.503
  
100         
 4 4.03 ± 0.220
Positive Control Dimethylbenzanthracene 
2.5       
 4 9.34 ± 0.542


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 05/12/87 42 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  42 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 4.70 ± 0.977
Test Chemical Quinoline 
25         
 4 3.71 ± 0.295
  
50         
 4 4.27 ± 0.441
  
100         
 4 4.21 ± 0.198
Positive Control Dimethylbenzanthracene 
2.5       
 4 9.27 ± 0.964


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed