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Study Information
Study Attribute Value
CEBS Accession Number: 002-02766-0018-0000-2
Chemical Name: Quinoline
CASRN: 91-22-5
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 745521_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 09/25/85 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0185
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 12.00 ± 1.31 0.0000
Test Chemical Quinoline 
25         
 8 1.75 ± 0.59 0.0469
  
50         
 8 1.25 ± 0.37 0.1274
  
100         
 8 2.50 ± 0.82 0.0100
Vehicle Control No Stressor 
 0         
 8 0.50 ± 0.33 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 05/20/87 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.4843
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 39.25 ± 5.50 0.0000
Test Chemical Quinoline 
25         
 8 4.25 ± 1.16 0.6335
  
50         
 8 6.00 ± 1.13 0.2166
  
100         
 8 4.50 ± 1.18 0.5668
Vehicle Control No Stressor 
 0         
 8 4.75 ± 1.31 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 10/17/88 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.6722
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 16.25 ± 1.49 0.0000
Test Chemical Quinoline 
25         
 8 2.00 ± 0.85 0.7570
  
50         
 8 1.25 ± 0.53 0.9351
  
100         
 8 2.25 ± 0.80 0.6747
Vehicle Control No Stressor 
 0         
 8 2.75 ± 1.00 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed