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Study Information
Study Attribute Value
CEBS Accession Number: 002-02769-0001-0000-7
Chemical Name: Reserpine
CASRN: 50-55-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 057864_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
No Activation  2  Questionable 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 06/02/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1042 432 0.415 8.64 26.0 3.746
Dimethyl Sulfoxide 
0         
 50 1041 416 0.400 8.32 26.0 0.000
Test Chemical Reserpine 
 0.16      
 50 1040 443 0.426 8.86 26.0 6.593 
 0.5       
 50 1045 407 0.389 8.14 26.0 -2.538 
1.6       
 50 1042 403 0.387 8.06 26.0 -3.218 
5         
 50 1048 413 0.394 8.26 26.0 -1.384 
16         
 0 0 0 0.000 0.00 26.0 N/A 
50         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.005     
 50 1038 1206 1.162 24.12 26.0 190.742
Mitomycin-C 
 0.01      
 50 1048 1931 1.843 38.62 26.0 361.082
Trend: -0.811        
Probability: 0.791        

Trial #: 2    Activation: No Activation    Date: 06/26/1982    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1048 394 0.376 7.88 26.0 9.037
Dimethyl Sulfoxide 
0         
 50 1047 361 0.345 7.22 26.0 0.000
Test Chemical Reserpine 
1         
 50 1045 413 0.395 8.26 26.0 14.623 
2         
 50 1046 439 0.420 8.78 26.0 21.723 
5         
 50 1043 399 0.383 7.98 26.0 10.950 
10         
 50 1045 408 0.390 8.16 26.0 13.236 
20         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.005     
 50 1041 1499 1.440 29.98 26.0 317.629
Mitomycin-C 
 0.01      
 50 1045 2078 1.989 41.56 26.0 476.725
Trend: 1.212        
Probability: 0.113        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/02/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1049 537 0.512 10.74 26.0 4.583
Dimethyl Sulfoxide 
0         
 50 1046 512 0.489 10.24 26.0 0.000
Test Chemical Reserpine 
 0.16      
 50 1045 541 0.518 10.82 26.0 5.765 
 0.5       
 50 1040 532 0.512 10.64 26.0 4.506 
1.6       
 50 1046 481 0.460 9.62 26.0 -6.055 
5         
 50 1053 512 0.486 10.24 26.0 -0.665 
16         
 50 1045 494 0.473 9.88 26.0 -3.423 
50         
 50 1041 469 0.451 9.38 26.0 -7.958 
160         
 50 1028 453 0.441 9.06 26.0 -9.974
Positive Control Cyclophosphamide 
1.5       
 50 1047 2049 1.957 40.98 26.0 299.813
Cyclophosphamide 
2         
 50 1042 3092 2.967 61.84 26.0 506.225
Trend: -2.757        
Probability: 0.997        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 06/29/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1040 554 0.533 11.08 26.0 8.519
Dimethyl Sulfoxide 
0         
 50 1041 511 0.491 10.22 26.0 0.000
Test Chemical Reserpine 
25         
 50 1042 446 0.428 8.92 26.0 -12.804 
50         
 50 1041 512 0.492 10.24 26.0 0.196 
100         
 50 1029 458 0.445 9.16 26.0 -9.327 
200         
 50 1043 492 0.472 9.84 26.0 -3.903 
300         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
2         
 50 1046 3257 3.114 65.14 26.0 534.331
Trend: -0.280        
Probability: 0.610