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Study Information
Study Attribute Value
CEBS Accession Number: 002-02769-0018-0000-5
Chemical Name: Reserpine
CASRN: 50-55-5
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 013797_SCE
Study Result: Negative


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 04/18/89 42 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  42 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 6.65 ± 0.403
Test Chemical Reserpine 
 0.13      
 4 6.29 ± 0.402
  
 0.25      
 4 6.74 ± 0.717
  
 0.5       
 4 7.70 ± 0.765
Positive Control Dimethylbenzanthracene 
2.5       
 4 16.69 ± 0.892


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 05/03/89 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 4.98 ± 0.509
Test Chemical Reserpine 
 0.13      
 4 4.92 ± 0.379
  
 0.2       
 4 4.73 ± 0.252
  
 0.5       
 4 5.00 ± 0.320
Positive Control Dimethylbenzanthracene 
2.5       
 4 9.91 ± 0.596


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed