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Study Information
Study Attribute Value
CEBS Accession Number: 002-02769-0019-0000-6
Chemical Name: Reserpine
CASRN: 50-55-5
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 013797_CA
Study Result: Positive

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 05/14/89 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.2093
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
25         
 8 14.25 ± 2.46 0.0000
Test Chemical Reserpine 
50         
 8 5.25 ± 0.84 0.0070
  
100         
 7 5.71 ± 1.34 0.0037
  
200         
 8 3.75 ± 1.10 0.0693
Vehicle Control No Stressor 
 0         
 8 2.00 ± 0.65 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 06/01/89 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.6194
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 11.50 ± 2.97 0.0000
Test Chemical Reserpine 
50         
 8 0.25 ± 0.25 0.9494
  
100         
 8 0.50 ± 0.33 0.8726
  
200         
 7 0.86 ± 0.40 0.6993
Vehicle Control No Stressor 
 0         
 8 1.25 ± 0.75 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 09/27/89 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0000
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
25         
 7 12.29 ± 1.41 0.0000
Test Chemical Reserpine 
50         
 8 7.25 ± 1.06 0.0000
  
100         
 8 8.25 ± 1.44 0.0000
  
150         
 8 10.25 ± 1.71 0.0000
Vehicle Control No Stressor 
 0         
 8 1.14 ± 0.38 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed