Genetic Toxicology - Mammalian Cell Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-02771-0015-0000-5
Chemical Name:	Resorcinol
CASRN:	108-46-3
NTP Study Type:	Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID:	743596
Study Result:	Positive

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Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Water	0	101	134	271	90	77
			79	98	156	66
			80	100	259	109
			82#	68	109.5	45
Test Chemical	Resorcinol	125	76	70	145	64	82
			61	74	182	100	82
		250	71	49	317	148	145*
			70	54	299	142	145*
		500	55	37	298	181	155*
			57	28	218	129	155*
		1000	73	31	312	143	135*
			79	36	299	126	135*
		2000	60	21	288	159
Positive Control	Ethyl Methane Sulfonate	250	55	55	372	227	201*
Positive Control			81	77	427	176	201*

Nonactivation Trial: 2 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Water	0	48r	82	121	85	58
			69	117	105	51
			52	83	102	66
			47r	94	123	87
Test Chemical	Resorcinol	156.25	57	83	190	112	94
			65#	109	147	76	94
		312.5	49	52	322	221	184*
			55	57	242	148	184*
		625	40	25	352	295	257*
			45	21	294	219	257*
		1250	29	12	220	249	212*
			40	19	211	176	212*
		2500	31	7	107	114	88
			51	11	93	61	88
		5000

Positive Control	Ethyl Methane Sulfonate	250	43	63	526	411	444*
Positive Control			37	48	533	478	444*

Nonactivation Trial: 3 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Water	0	75	118	169	75	65
			76	114	162	71
			58	80	99	57
			71	89	119	56
Test Chemical	Resorcinol	156.25	65	83	234	121	113*
			75	106	239	106	113*
		312.5	56	71	312	187	190*
			60	73	344	192	190*
		625	52	33	454	292	290*
			57	32	491	288	290*
		1250	43	24	225	174	148*
			56	29	206	122	148*
		2500	36	7	195	179	175*
			39	8	201	172	175*
		5000

Positive Control	Ethyl Methane Sulfonate	250	60	76	789	436	459*
Positive Control			51	69	731	483	459*

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination