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Study Information
Study Attribute Value
CEBS Accession Number: 002-02779-0001-0000-8
Chemical Name: Rhodamine 6G
CASRN: 989-38-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 199566_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Questionable 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 07/09/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Ethanol 
0         
 50 1036 386 0.373 7.72 26.5 0.000
Test Chemical Rhodamine 6G 
 0.0396    
 50 1037 362 0.349 7.24 26.5 -6.308 
 0.132     
 50 1034 307 0.297 6.14 26.5 -20.312 
 0.396     
 50 1041 335 0.322 6.70 31.0 -13.629 
 0.396     
 50 1035 336 0.325 6.72 26.5 -12.869 
1.32      
 0 0 0 0.000 0.00 31.0 N/A
Positive Control Mitomycin-C 
 0.0015    
 50 1036 512 0.494 10.24 26.5 32.642
Mitomycin-C 
 0.01      
 10 208 208 1.000 20.80 26.5 168.394
Trend: -2.436        
Probability: 0.993        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/09/1985    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Ethanol 
0         
 50 1046 486 0.465 9.72 26.0 0.000
Test Chemical Rhodamine 6G 
1.32      
 50 1046 466 0.446 9.32 26.0 -4.115 
3.96      
 50 1044 499 0.478 9.98 26.0 2.872 
13.2       
 50 1047 580 0.554 11.60 26.0 19.228 
39.6       
 0 0 0 0.000 0.00 30.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1048 583 0.556 11.66 26.0 19.730
Cyclophosphamide 
2.5       
 10 210 253 1.205 25.30 26.0 159.296
Trend: 3.149        
Probability: 0.001        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 09/18/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Ethanol 
0         
 50 1035 483 0.467 9.66 26.0 0.000
Test Chemical Rhodamine 6G 
9.95      
 50 1039 635 0.611 12.70 26.0 30.964 
15         
 50 1046 576 0.551 11.52 26.0 18.001 
19.9       
 50 1038 722 0.696 14.44 30.0 49.050 
24.9       
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
 0.5       
 50 1043 618 0.593 12.36 26.0 26.969
Cyclophosphamide 
2.5       
 10 210 308 1.467 30.80 26.0 214.286
Trend: 5.629        
Probability: 0.000