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Study Information
Study Attribute Value
CEBS Accession Number: 002-02781-0001-0000-1
Chemical Name: Ribavirin
CASRN: 36791-04-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 048858_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 05/22/1991    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1039 403 0.388 8.06 26.0 0.000
Dimethyl Sulfoxide 
0         
 50 1047 379 0.362 7.58 31.0 -6.674
Test Chemical Ribavirin 
2.5       
 50 1048 473 0.451 9.46 26.0 16.362 
8.3       
 50 1040 513 0.493 10.26 26.0 27.173 
25         
 25 523 450 0.860 18.00 31.0 121.831 
83         
 0 0 0 0.000 0.00 31.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1050 613 0.584 12.26 26.0 50.516
Mitomycin-C 
 0.004     
 10 210 243 1.157 24.30 26.0 198.330
Trend: 10.812        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 07/25/1991    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 394 0.376 7.88 31.0 4.887
Dimethyl Sulfoxide 
0         
 50 1050 376 0.358 7.52 26.0 0.000
Test Chemical Ribavirin 
10         
 50 1048 432 0.412 8.64 26.0 15.113 
15         
 50 1050 666 0.634 13.32 31.0 77.128 
25         
 50 1051 877 0.834 17.54 31.0 133.023
Positive Control Mitomycin-C 
 0.001     
 50 1050 486 0.463 9.72 26.0 29.255
Mitomycin-C 
 0.004     
 10 210 200 0.952 20.00 26.0 165.957
Trend: 15.994        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 05/22/1991    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1048 447 0.427 8.94 26.0 9.528
Dimethyl Sulfoxide 
0         
 50 1040 405 0.389 8.10 26.0 0.000
Test Chemical Ribavirin 
250         
 50 1043 413 0.396 8.26 26.0 1.682 
833         
 50 1042 423 0.406 8.46 26.0 4.244 
2500         
 50 1044 415 0.398 8.30 26.0 2.077
Positive Control Cyclophosphamide 
 0.125     
 50 1050 505 0.481 10.10 26.0 23.504
Cyclophosphamide 
 0.5       
 10 210 180 0.857 18.00 26.0 120.106
Trend: 0.399        
Probability: 0.345