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Study Information
Study Attribute Value
CEBS Accession Number: 002-02783-0001-0000-3
Chemical Name: Riddelliine
CASRN: 23246-96-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 762742_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 09/22/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1031 432 0.419 8.64 25.5 0.000
Test Chemical Riddelliine 
30         
 50 1028 538 0.523 10.76 25.5 24.900 
100         
 50 1040 702 0.675 14.04 25.5 61.094 
300         
 50 1036 1224 1.181 24.48 25.5 181.966
Positive Control Mitomycin-C 
 0.001     
 50 1022 671 0.657 13.42 25.5 56.692
Mitomycin-C 
 0.01      
 5 105 240 2.286 48.00 25.5 445.503
Trend: 20.835        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 09/22/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1018 432 0.424 8.64 26.0 0.000
Test Chemical Riddelliine 
3         
 50 1017 1537 1.511 30.74 26.0 256.137 
10         
 20 408 1539 3.772 76.95 26.0 788.879 
30         
 3 63 441 7.000 147.00 26.0 1549.537 
100         
 0 0 0 0.000 0.00 35.0 N/A
Positive Control Cyclophosphamide 
 0.3       
 50 1009 538 0.533 10.76 26.0 25.648
Cyclophosphamide 
2         
 5 101 141 1.396 28.20 26.0 228.974
Trend: 55.032        
Probability: 0.000