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Study Information
Study Attribute Value
CEBS Accession Number: 002-02784-0001-0000-4
Chemical Name: Rotenone
CASRN: 83-79-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 195015_SCE
Study Result: Not a Valid Test

Study Result: Not a Valid Test
Activation Trial Trial Call
No Activation  1  Test Failure 
Induced Rat Liver S9  1_S9  Test Failure 
Induced Rat Liver S9  2_S9  Test Failure 

Trial #: 1    Activation: No Activation    Date: 01/23/1985    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1012 572 0.565 11.44 26.0 -1.087
Acetone 
0         
 50 1008 576 0.571 11.52 34.5 0.000
Test Chemical Rotenone 
 0.001     
 50 1003 585 0.583 11.70 34.5 2.069 
 0.0025    
 50 1007 666 0.661 13.32 34.5 15.740 
 0.004     
 0 0 0 0.000 0.00 34.5 N/A 
 0.0075    
 0 0 0 0.000 0.00 34.5 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1002 690 0.689 13.80 26.0 20.509
Mitomycin-C 
 0.01      
 5 104 193 1.856 38.60 26.0 224.760
Trend: 2.682        
Probability: 0.004        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 11/15/1984    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Acetone 
0         
 50 1020 386 0.378 7.72 26.0 0.000
Negative (Not Specified) 
0         
 50 1031 497 0.482 9.94 26.0 27.383
Test Chemical Rotenone 
 0.2       
 50 1017 450 0.442 9.00 34.0 16.924 
 0.6       
 50 1037 531 0.512 10.62 34.0 35.310 
2         
 9 188 97 0.516 10.78 34.0 36.341 
6         
 15 307 145 0.472 9.67 34.0 24.808 
20         
 0 0 0 0.000 0.00 34.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1027 604 0.588 12.08 26.0 55.410
Cyclophosphamide 
2         
 5 105 187 1.781 37.40 26.0 370.614
Trend: 3.774        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 01/23/1985    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1024 596 0.582 11.92 26.0 -1.673
Acetone 
0         
 50 1017 602 0.592 12.04 26.0 0.000
Test Chemical Rotenone 
6         
 50 1012 590 0.583 11.80 34.5 -1.509 
10.1       
 50 1010 611 0.605 12.22 34.5 2.198 
15.2       
 50 1002 598 0.597 11.96 34.5 0.823 
20         
 0 0 0 0.000 0.00 34.5 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1006 831 0.826 16.62 26.0 39.549
Cyclophosphamide 
2         
 5 102 177 1.735 35.40 26.0 193.155
Trend: 0.366        
Probability: 0.357