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Study Information
Study Attribute Value
CEBS Accession Number: 002-02784-0003-0000-6
Chemical Name: Rotenone
CASRN: 83-79-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 743095_SCE
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 08/04/1988    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Acetone 
0         
 50 1042 464 0.445 9.28 26.0 0.000
Test Chemical Rotenone 
 0.0E-4    
 50 1032 499 0.484 9.98 26.0 8.585 
 0.0E-4    
 50 1040 475 0.457 9.50 26.0 2.568 
 0.0E-4    
 50 1032 514 0.498 10.28 26.0 11.849 
 0.0016    
 50 1038 540 0.520 10.80 26.0 16.828
Positive Control Mitomycin-C 
 0.0E-4    
 50 1036 616 0.595 12.32 26.0 33.527
Mitomycin-C 
 0.005     
 10 207 285 1.377 28.50 26.0 209.189
Trend: 2.496        
Probability: 0.006        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/22/1988    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Acetone 
0         
 50 1045 425 0.407 8.50 26.0 0.000
Test Chemical Rotenone 
 0.05      
 50 1041 445 0.427 8.90 26.0 5.108 
 0.16      
 50 1039 530 0.510 10.60 26.0 25.426 
 0.5       
 50 1036 455 0.439 9.10 26.0 7.989 
1.6       
 34 707 351 0.496 10.32 26.0 22.072
Positive Control Cyclophosphamide 
 0.15      
 50 1045 615 0.589 12.30 26.0 44.706
Cyclophosphamide 
 0.6       
 10 210 197 0.938 19.70 26.0 130.661
Trend: 2.683        
Probability: 0.004        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 09/13/1988    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Acetone 
0         
 50 1050 395 0.376 7.90 26.0 0.000
Test Chemical Rotenone 
 0.05      
 50 1049 468 0.446 9.36 26.0 18.594 
 0.16      
 50 1050 458 0.436 9.16 26.0 15.949 
 0.5       
 50 1050 462 0.440 9.24 26.0 16.962 
1.6       
 50 1043 481 0.461 9.62 26.0 22.589
Positive Control Cyclophosphamide 
 0.1       
 50 1050 531 0.506 10.62 26.0 34.430
Cyclophosphamide 
 0.6       
 10 209 220 1.053 22.00 26.0 179.813
Trend: 2.553        
Probability: 0.005