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Study Information
Study Attribute Value
CEBS Accession Number: 002-02785-0001-0000-5
Chemical Name: Roxarsone
CASRN: 121-19-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 580937_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 10/27/1987    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 465 0.443 9.30 26.0 0.000
Test Chemical Roxarsone 
50         
 50 1049 468 0.446 9.36 26.0 0.741 
160         
 50 1044 404 0.387 8.08 26.0 -12.619 
500         
 50 1051 459 0.437 9.18 26.0 -1.384 
1000         
 50 1049 528 0.503 10.56 26.0 13.657
Positive Control Mitomycin-C 
 0.0E-4    
 50 1043 561 0.538 11.22 26.0 21.455
Mitomycin-C 
 0.005     
 10 210 252 1.200 25.20 26.0 170.968
Trend: 1.492        
Probability: 0.068        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/27/1987    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 397 0.378 7.94 26.0 0.000
Test Chemical Roxarsone 
50         
 50 1050 375 0.357 7.50 26.0 -5.632 
160         
 50 1047 378 0.361 7.56 26.0 -4.604 
500         
 50 1050 410 0.390 8.20 26.0 3.176 
1000         
 50 1050 396 0.377 7.92 26.0 -0.347
Positive Control Cyclophosphamide 
 0.1       
 50 1045 474 0.454 9.48 26.0 19.852
Cyclophosphamide 
 0.6       
 10 209 215 1.029 21.50 26.0 171.817
Trend: 0.555        
Probability: 0.290