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Study Information
Study Attribute Value
CEBS Accession Number: 002-02793-0001-0000-4
Chemical Name: Salicylazosulfapyridine
CASRN: 599-79-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 291257_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 09/29/1988    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1033 475 0.460 9.50 26.0 0.000
Test Chemical Salicylazosulfapyridine 
1.6       
 50 1029 381 0.370 7.62 26.0 -19.478 
16         
 50 1032 395 0.383 7.90 26.0 -16.762 
50         
 50 1030 388 0.377 7.76 26.0 -18.078 
160         
 50 1022 444 0.434 8.88 26.0 -5.520
Positive Control Mitomycin-C 
 0.0E-4    
 50 1039 667 0.642 13.34 26.0 39.610
Mitomycin-C 
 0.005     
 10 207 247 1.193 24.70 26.0 159.498
Trend: -0.973        
Probability: 0.835        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 09/29/1988    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 398 0.380 7.96 26.0 0.000
Test Chemical Salicylazosulfapyridine 
50         
 50 1034 398 0.385 7.96 26.0 1.257 
160         
 50 1036 415 0.401 8.30 26.0 5.378 
500         
 50 1034 364 0.352 7.28 26.0 -7.393 
1000         
 50 1029 380 0.369 7.60 26.0 -2.852
Positive Control Cyclophosphamide 
 0.1       
 50 1049 485 0.462 9.70 26.0 21.627
Cyclophosphamide 
 0.6       
 10 210 137 0.652 13.70 26.0 71.619
Trend: -0.935        
Probability: 0.825