Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02793-0002-0000-5 |
Chemical Name: | Salicylazosulfapyridine |
CASRN: | 599-79-1 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 291257_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
Test Chemical: | Salicylazosulfapyridine | 300 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
500 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | ||
1000 | 200 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.125 | 200 | 54 | 0.270 | 21.5 | 21 | 0.105 | 10.0 | 33 | 0.165 | 15.0 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.25 | 50 | 33 | 0.660 | 34.0 | 7 | 0.140 | 14.0 | 16 | 0.320 | 24.0 | 10 | 0.200 | 1.0 | |
Trend: | 0.909 | 1.395 | 0.242 | ||||||||||||
Probability: | 0.182 | 0.081 | 0.404 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 4 | 0.020 | 1.5 | 0 | 0.000 | 0.0 | 4 | 0.020 | 1.5 | 0 | 0.000 | 0.0 |
Test Chemical: | Salicylazosulfapyridine | 300 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
500 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | ||
1000 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 5 | 200 | 29 | 0.145 | 13.5 | 8 | 0.040 | 4.0 | 21 | 0.105 | 10.0 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 7.5 | 50 | 23 | 0.460 | 42.0 | 4 | 0.080 | 8.0 | 18 | 0.360 | 34.0 | 1 | 0.020 | 1.0 | |
Trend: | -1.815 | 0.000 | -1.815 | ||||||||||||
Probability: | 0.965 | 0.000 | 0.965 |