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Study Information
Study Attribute Value
CEBS Accession Number: 002-02793-0021-0000-6
Chemical Name: Salicylazosulfapyridine
CASRN: 599-79-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 724355_SCE
Study Result: Negative (Nonstandard Protocol)


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 11/07/90 17 Mouse Male B6C3F1 Bone Marrow Gavage x 1,  17 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 5 5.47 ± 0.714
Test Chemical Salicylazosulfapyridine 
1250         
 5 4.10 ± 0.339
  
2500         
 5 4.22 ± 0.394
  
5000         
 5 4.27 ± 0.421
Positive Control Mitomycin-C 
1         
 5 12.24 ± 1.829


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 11/07/90 24 Mouse Male B6C3F1 Bone Marrow subcutaneously implanted x 1,  24 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 5 4.05 ± 0.377
Test Chemical Salicylazosulfapyridine 
1250         
 5 4.18 ± 0.535
  
2500         
 5 4.48 ± 0.597
  
5000         
 5 3.87 ± 0.531
Positive Control Mitomycin-C 
 0.5       
 5 7.77 ± 0.594


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed