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Study Information
Study Attribute Value
CEBS Accession Number: 002-02797-0001-0000-8
Chemical Name: Selenium sulfide
CASRN: 7446-34-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 807686_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 08/15/1985    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 357 0.341 7.14 26.5 0.000
Test Chemical Selenium sulfide 
 0.1       
 50 1045 410 0.392 8.20 26.5 15.066 
 0.3       
 50 1048 367 0.350 7.34 26.5 2.703 
1         
 50 1043 387 0.371 7.74 26.5 8.819 
3         
 31 648 509 0.785 16.42 30.5 130.368 
10         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.0015    
 50 1044 545 0.522 10.90 26.5 53.100
Mitomycin-C 
 0.01      
 10 210 229 1.090 22.90 26.5 219.812
Trend: 10.146        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 08/27/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1044 310 0.297 6.20 26.5 0.000
Negative (Not Specified) 
0         
 50 1041 308 0.296 6.16 26.5 -0.359
Test Chemical Selenium sulfide 
1         
 50 1043 406 0.389 8.12 26.5 31.093 
2         
 50 1036 566 0.546 11.32 26.5 83.991 
2.5       
 50 1041 543 0.522 10.86 26.5 75.666 
3         
 50 1043 740 0.709 14.80 26.5 138.939 
4         
 0 0 0 0.000 0.00 26.5 N/A
Positive Control Mitomycin-C 
 0.0015    
 50 1038 465 0.448 9.30 26.5 50.867
Mitomycin-C 
 0.01      
 10 211 224 1.062 22.40 26.5 257.523
Trend: 13.744        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 08/15/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 378 0.362 7.56 26.0 0.000
Test Chemical Selenium sulfide 
 0.3       
 50 1051 426 0.405 8.52 26.0 12.055 
1         
 50 1050 439 0.418 8.78 26.0 15.585 
3         
 50 1043 389 0.373 7.78 26.0 3.107 
10         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1041 811 0.779 16.22 26.0 115.375
Cyclophosphamide 
2.5       
 10 207 423 2.043 42.30 26.0 464.930
Trend: 0.575        
Probability: 0.283