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Study Information
Study Attribute Value
CEBS Accession Number: 002-02797-0002-0000-9
Chemical Name: Selenium sulfide
CASRN: 7446-34-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 807686_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive* 
Induced Rat Liver S9  1_S9  Weakly Positive 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 08/22/1985    Harvest Time: 10.5 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 1.0 0 0.000 0.0
Test Chemical: Selenium sulfide 
 0.498     
 200 8 0.040 4.0 1 0.005 1.0 7 0.035 4.0 0 0.000 0.0 
1.5       
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 1.0 0 0.000 0.0 
2.99      
 200 8 0.040 4.0 2 0.010 1.0 6 0.030 3.0 0 0.000 0.0 
4.98      
 200 44 0.220 12.5 13 0.065 6.0 21 0.105 7.0 10 0.050 1.0 
9.96      
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
1         
 200 45 0.225 16.5 9 0.045 4.0 25 0.125 12.0 11 0.055 2.0
Mitomycin-C 
5         
 50 28 0.560 42.0 11 0.220 20.0 17 0.340 30.0 0 0.000 0.0
Trend: 4.709 3.802 2.431  
Probability: 0.000 0.000 0.008  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 08/22/1985    Harvest Time: 12 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 4 0.020 2.0 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: Selenium sulfide 
 0.995     
 200 13 0.065 5.0 3 0.015 2.0 10 0.050 4.0 0 0.000 0.0 
2.99      
 200 2 0.010 0.5 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
4.98      
 200 7 0.035 3.5 0 0.000 0.0 7 0.035 4.0 0 0.000 0.0 
9.96      
 13 45 3.462 53.8 3 0.231 23.0 2 0.154 8.0 40 3.077 4.0
Positive Control: Cyclophosphamide 
50         
 50 20 0.400 28.0 6 0.120 12.0 14 0.280 16.0 0 0.000 0.0
Trend: 2.090 0.256 1.190  
Probability: 0.018 0.399 0.117  


Trial #:2   Activation: No Activation    Date: 08/29/1985    Harvest Time: 10.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 6 0.030 3.0 0 0.000 0.0 6 0.030 3.0 0 0.000 0.0
Test Chemical: Selenium sulfide 
3         
 200 7 0.035 3.0 1 0.005 1.0 6 0.030 3.0 0 0.000 0.0 
4         
 200 12 0.060 5.5 3 0.015 2.0 9 0.045 5.0 0 0.000 0.0 
5         
 200 23 0.115 10.0 9 0.045 4.0 14 0.070 7.0 0 0.000 0.0 
7.5       
 5 9 1.800 80.0 1 0.200 20.0 8 1.600 60.0 0 0.000 0.0 
10         
 18 28 1.556 44.4 8 0.444 28.0 10 0.556 33.0 10 0.556 1.0
Positive Control: Mitomycin-C 
1         
 200 47 0.235 20.5 11 0.055 5.0 36 0.180 17.0 0 0.000 0.0
Mitomycin-C 
5         
 50 26 0.520 38.0 6 0.120 12.0 20 0.400 30.0 0 0.000 0.0
Trend: 6.661 6.005 5.006  
Probability: 0.000 0.000 0.000