Genetic Toxicology - Mammalian Cell Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-02797-0013-0000-1
Chemical Name:	Selenium sulfide
CASRN:	7446-34-6
NTP Study Type:	Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID:	124703
Study Result:	Positive

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Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Ethanol	0	121r	102	102	28	25
			121r	107	92	25
			114	90	89	26
			113	110	82	24
Test Chemical	Selenium sulfide	0.125	108	48	82	25	28
			99	46	79	27
			99	56	93	31
		0.25	117	30	157	45	50*
			81	26	136	56
			91	33	131	48
		0.5	90	21	158	59	70*
			84	20	188	75
			74	20	169	77
		0.75	59	3	301	170	159*
			77	7	367	160
			104	12	458	147
		1	46	2	224	164	162*
			71#	3	356	167
			68	2	319	156
		2


Positive Control	Methyl Methane Sulfonate	5	43#	20	1280	1000	720*
			61	38	1001	546
			63	37	1169	615

Nonactivation Trial: 2 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Ethanol	0	87	108	43	16	24
			89	84	90	34
			73	99	42	19
			67	110	53	26
Test Chemical	Selenium sulfide	0.125	92	189	153	56	54*
			119	119	168	47
			118	94	214	60
		0.25	51	28	252	164	100*
			61	36	141	77
			85	42	152	59
		0.5	104	11	287	92	106*
			57	8	205	119	106*
		0.75


Positive Control	Methyl Methane Sulfonate	5	31	24	647	688	502*
			23	22	265	393
			37	38	465	425

Induced S9 Trial: 1 Experiment Call: Negative and Non-Toxic
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Ethanol	0	100	103	201	67	63
			70#	97	141	67
			116	104	208	60
			96	96	166	58
Test Chemical	Selenium sulfide	0.5	111	94	162	49	51
			116	98	181	52
			113	107	179	53
		0.75	120	67	186	52	50
			111	91	171	52
			93#	83	129	46
		1	113	66	200	59	68
			72	59	165	77
			120r	96	184	51
		2	116	80	184	53	53
			111	98	187	56
			113	56	168	50
		4	110	75	211	64	54
			117	73	213	61
			101	78	115	38
		6	118	85	210	59	58
			114	74	206	60
			104	62	171	55
Positive Control	3-Methylcholanthrene	2.5	99	27	854	288	342*
			74	30	890	403
			73	38	739	337

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination