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Study Information
Study Attribute Value
CEBS Accession Number: 002-02797-0013-0000-1
Chemical Name: Selenium sulfide
CASRN: 7446-34-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 124703
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Ethanol 
 0         
 121r 102 102 28 25
    121r 107 92 25
    114 90 89 26
    113 110 82 24
Test Chemical Selenium sulfide 
 0.125     
 108 48 82 25 28
    99 46 79 27
    99 56 93 31
  
 0.25      
 117 30 157 45 50*
    81 26 136 56
    91 33 131 48
  
 0.5       
 90 21 158 59 70*
    84 20 188 75
    74 20 169 77
  
 0.75      
 59 3 301 170 159*
    77 7 367 160
    104 12 458 147
  
1         
 46 2 224 164 162*
    71# 3 356 167
    68 2 319 156
  
2         
   
   
Positive Control Methyl Methane Sulfonate 
5         
 43# 20 1280 1000 720*
    61 38 1001 546
    63 37 1169 615

Nonactivation Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Ethanol 
 0         
 87 108 43 16 24
    89 84 90 34
    73 99 42 19
    67 110 53 26
Test Chemical Selenium sulfide 
 0.125     
 92 189 153 56 54*
    119 119 168 47
    118 94 214 60
  
 0.25      
 51 28 252 164 100*
    61 36 141 77
    85 42 152 59
  
 0.5       
 104 11 287 92 106*
    57 8 205 119
  
 0.75      
   
   
Positive Control Methyl Methane Sulfonate 
5         
 31 24 647 688 502*
    23 22 265 393
    37 38 465 425

Induced S9 Trial: 1 Experiment Call: Negative and Non-Toxic
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Ethanol 
 0         
 100 103 201 67 63
    70# 97 141 67
    116 104 208 60
    96 96 166 58
Test Chemical Selenium sulfide 
 0.5       
 111 94 162 49 51
    116 98 181 52
    113 107 179 53
  
 0.75      
 120 67 186 52 50
    111 91 171 52
    93# 83 129 46
  
1         
 113 66 200 59 68
    72 59 165 77
    120r 96 184 51
  
2         
 116 80 184 53 53
    111 98 187 56
    113 56 168 50
  
4         
 110 75 211 64 54
    117 73 213 61
    101 78 115 38
  
6         
 118 85 210 59 58
    114 74 206 60
    104 62 171 55
Positive Control 3-Methylcholanthrene 
2.5       
 99 27 854 288 342*
    74 30 890 403
    73 38 739 337

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination