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Study Information
Study Attribute Value
CEBS Accession Number: 002-02797-0014-0000-2
Chemical Name: Selenium sulfide
CASRN: 7446-34-6
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 023793_SCE
Study Result: Positive


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 12/20/88 42 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  42 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 5.92 ± 0.203
Test Chemical Selenium sulfide 
3.75      
 4 5.30 ± 0.613
  
7.5       
 4 7.53 ± 0.718
  
15         
 4 8.57 ± 0.290
Positive Control Dimethylbenzanthracene 
25         
 4 19.18 ± 0.690


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 02/15/89 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 4.35 ± 0.381
Test Chemical Selenium sulfide 
3.75      
 4 5.44 ± 0.603
  
7.5       
 4 4.71 ± 0.201
  
15         
 4 4.63 ± 0.216
Positive Control Dimethylbenzanthracene 
2.5       
 4 8.21 ± 0.303


Summary of Sister Chromatid Exchange Data (Trial 3)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 04/18/89 42 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  42 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 6.65 ± 0.403
Test Chemical Selenium sulfide 
11.25      
 4 10.70 ± 0.183
  
15         
 4 10.73 ± 1.957
Positive Control Dimethylbenzanthracene 
2.5       
 4 16.69 ± 0.892


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed