Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02806-0002-0000-0 |
Chemical Name: | Sodium (2-ethylhexyl)alcohol sulfate |
CASRN: | 126-92-1 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 316678_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Medium | 0 | 100 | 4 | 0.040 | 3.0 | 0 | 0.000 | 0.0 | 4 | 0.040 | 3.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Sodium (2-ethylhexyl)alcohol sulfate | 501 | 100 | 5 | 0.050 | 5.0 | 0 | 0.000 | 0.0 | 5 | 0.050 | 5.0 | 0 | 0.000 | 0.0 |
1500 | 100 | 4 | 0.040 | 4.0 | 0 | 0.000 | 0.0 | 4 | 0.040 | 4.0 | 0 | 0.000 | 0.0 | ||
5010 | 100 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 1 | 100 | 26 | 0.260 | 20.0 | 8 | 0.080 | 7.0 | 18 | 0.180 | 15.0 | 0 | 0.000 | 0.0 |
Mitomycin-C | 5 | 50 | 29 | 0.580 | 26.0 | 3 | 0.060 | 4.0 | 16 | 0.320 | 22.0 | 10 | 0.200 | 1.0 | |
Trend: | -0.495 | 0.000 | -0.495 | ||||||||||||
Probability: | 0.690 | 0.000 | 0.690 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Medium | 0 | 100 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Sodium (2-ethylhexyl)alcohol sulfate | 501 | 100 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 |
1500 | 100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
5010 | 100 | 8 | 0.080 | 7.0 | 1 | 0.010 | 1.0 | 7 | 0.070 | 6.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 50 | 50 | 31 | 0.620 | 34.0 | 4 | 0.080 | 6.0 | 17 | 0.340 | 26.0 | 10 | 0.200 | 1.0 |
Trend: | 1.421 | 1.360 | 1.078 | ||||||||||||
Probability: | 0.078 | 0.087 | 0.140 |