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Study Information
Study Attribute Value
CEBS Accession Number: 002-02806-0007-0000-5
Chemical Name: Sodium (2-ethylhexyl)alcohol sulfate
CASRN: 126-92-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 795640_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 07/27/88 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0585
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 9.00 ± 1.89 0.0000
Test Chemical Sodium (2-ethylhexyl)alcohol sulfate 
275         
 8 3.00 ± 1.07 0.0431
  
550         
 8 4.00 ± 0.53 0.0075
  
1100         
 8 3.25 ± 1.00 0.0282
Vehicle Control No Stressor 
 0         
 8 1.25 ± 0.75 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 12/13/88 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.6161
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 22.00 ± 3.32 0.0000
Test Chemical Sodium (2-ethylhexyl)alcohol sulfate 
275         
 8 2.25 ± 0.96 0.1404
  
550         
 8 2.00 ± 1.46 0.2008
  
1100         
 8 1.25 ± 0.75 0.5000
Vehicle Control No Stressor 
 0         
 8 1.25 ± 0.53 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 12/03/91 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0029
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 4.75 ± 1.25 0.0000
Test Chemical Sodium (2-ethylhexyl)alcohol sulfate 
250         
 8 0.50 ± 0.50 0.2815
  
500         
 8 1.00 ± 0.65 0.0892
  
1000         
 8 2.00 ± 0.65 0.0095
Vehicle Control No Stressor 
 0         
 8 0.25 ± 0.25 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 01/11/93 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.2034
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 14.50 ± 1.76 0.0000
Test Chemical Sodium (2-ethylhexyl)alcohol sulfate 
250         
 7 2.00 ± 0.76 0.0299
  
500         
 8 1.25 ± 0.53 0.1274
  
1000         
 8 1.50 ± 0.98 0.0776
Vehicle Control No Stressor 
 0         
 8 0.50 ± 0.50 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 08/16/93 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.2178
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 22.00 ± 2.20 0.0000
Test Chemical Sodium (2-ethylhexyl)alcohol sulfate 
250         
 8 1.00 ± 0.53 0.7378
  
500         
 8 0.75 ± 0.37 0.8427
  
1000         
 8 2.00 ± 0.85 0.2949
Vehicle Control No Stressor 
 0         
 8 1.50 ± 0.73 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed