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Study Information
Study Attribute Value
CEBS Accession Number: 002-02810-0001-0000-4
Chemical Name: Sodium azide
CASRN: 26628-22-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 166603_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Weakly Positive 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 10/27/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1050 324 0.309 6.48 25.8 0.000
Test Chemical Sodium azide 
1.34      
 50 1048 361 0.344 7.22 25.8 11.632 
4.02      
 50 1050 441 0.420 8.82 25.8 36.111 
13.4       
 50 1047 436 0.416 8.72 33.5 34.953 
40.2       
 0 0 0 0.000 0.00 33.5 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1050 709 0.675 14.18 25.8 118.827
Mitomycin-C 
 0.01      
 5 105 223 2.124 44.60 25.8 588.272
Trend: 4.705        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 11/03/1987    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1049 329 0.314 6.58 25.7 0.000
Test Chemical Sodium azide 
13.4       
 50 1049 320 0.305 6.40 25.7 -2.736 
26.8       
 50 1047 366 0.350 7.32 31.7 11.459 
40.2       
 50 1041 413 0.397 8.26 31.7 26.497
Positive Control Mitomycin-C 
 0.001     
 50 1049 541 0.516 10.82 25.7 64.438
Mitomycin-C 
 0.01      
 5 105 181 1.724 36.20 25.7 449.628
Trend: 3.577        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/27/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1050 371 0.353 7.42 25.8 0.000
Test Chemical Sodium azide 
402         
 50 1050 390 0.371 7.80 25.8 5.121 
1340         
 50 1049 448 0.427 8.96 25.8 20.870 
4020         
 50 1050 620 0.590 12.40 25.8 67.116
Positive Control Cyclophosphamide 
 0.4       
 50 1050 813 0.774 16.26 25.8 119.137
Cyclophosphamide 
2         
 5 105 210 2.000 42.00 25.8 466.038
Trend: 8.374        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 11/03/1987    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1040 318 0.306 6.36 25.7 0.000
Test Chemical Sodium azide 
1340         
 50 1049 300 0.286 6.00 25.7 -6.470 
2068         
 50 1044 299 0.286 5.98 25.7 -6.335 
4020         
 50 1050 402 0.383 8.04 25.7 25.211
Positive Control Cyclophosphamide 
 0.4       
 50 1045 593 0.567 11.86 25.7 85.586
Cyclophosphamide 
2         
 5 102 155 1.520 31.00 25.7 396.979
Trend: 3.208        
Probability: 0.001