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Study Information
Study Attribute Value
CEBS Accession Number: 002-02811-0002-0000-6
Chemical Name: Sodium bifluoride
CASRN: 51273-71-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 130535
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 86# 103 82 32 27
    87 104 63 24
    83 93 61 24
Test Chemical Sodium bifluoride 
25         
 84 73 51 20 38
    75 82 56 25
    45 41 92 68
  
50         
 65# 75 47 24 38
    65 84 79 41
    93 51 133 48
  
100         
 67# 63 46 23 20
    95 93 49 17
  
200         
 77 46 82 35 29
    79 50 72 31
    87 62 53 20
  
300         
 94# 42 163 58 54*
    72 23 134 62
    69# 38 88 42
  
400         
 71# 16 122 57 69*
    66# 3 159 80
  
500         
   
   
Positive Control Methyl Methane Sulfonate 
5         
 74 62 480 218 200*
    90# 58 472 175
    84 64 516 206

Nonactivation Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 70 90 43 20 16
    76# 108 30 13
    76 98 38 17
    97 104 45 15
Test Chemical Sodium bifluoride 
25         
 34 42 100 97 77*
    30 36 74 83
    56 55 88 52
  
50         
 44 60 62 47 53*
    66 92 71 36
    33 42 76 76
  
100         
 62 70 83 44 44*
    66 83 61 31
    61 54 102 56
  
200         
 48 45 86 59 66*
    72 49 136 63
    52 48 116 75
  
300         
 54 21 59 36 43*
    68 18 113 55
    57 23 64 37
  
400         
 67 6 110 54 132*
    30 2 162 180
    42 3 205 161
  
500         
   
   
Positive Control Methyl Methane Sulfonate 
5         
 65 57 474 245 220*
    58 44 162 92
    46 45 444 324

Nonactivation Trial: 3 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 18
    104 64 56 18
    123r 109 88 24
    112 136 64 19
Test Chemical Sodium bifluoride 
100         
 98 94 77 26 29
    107 69 92 29
    120 129 111 31
  
200         
 114 73 108 32 36*
    107 61 111 35
    116 77 141 41
  
250         
 106 53 164 51 42*
    110 87 93 28
    101 67 144 47
  
300         
 105 36 148 47 42*
    105 46 110 35
    87 31 118 45
  
350         
 108 14 204 63 54*
    116 23 206 59
    98 14 115 39
  
400         
 43*
    115 29 114 33
    99# 7 156 53
  
500         
   
   
Positive Control Methyl Methane Sulfonate 
5         
 98 39 874 299 277*
    83 26 710 284
    104 76 773 249

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination