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Study Information
Study Attribute Value
CEBS Accession Number: 002-02814-0001-0000-8
Chemical Name: Sodium chloride
CASRN: 7647-14-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 118875_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
No Activation  2  Test Failure 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 01/11/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1049 402 0.383 8.04 26.5 0.000
Test Chemical Sodium chloride 
160         
 50 1050 417 0.397 8.34 25.5 3.633 
500         
 50 1050 370 0.352 7.40 26.5 -8.048 
1600         
 50 1050 387 0.369 7.74 26.5 -3.823 
5000         
 50 1048 479 0.457 9.58 26.5 19.268
Positive Control Mitomycin-C 
 0.001     
 50 1050 602 0.573 12.04 26.5 49.609
Mitomycin-C 
 0.005     
 10 209 277 1.325 27.70 26.5 245.846
Trend: 1.947        
Probability: 0.026        

Trial #: 2    Activation: No Activation    Date: 03/14/1985    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1048 446 0.426 8.92 26.0 0.000
Test Chemical Sodium chloride 
2000         
 50 1047 424 0.405 8.48 27.5 -4.842 
3000         
 50 1048 366 0.349 7.32 27.5 -17.937 
4000         
 50 1048 412 0.393 8.24 27.5 -7.623 
5000         
 50 1050 370 0.352 7.40 27.5 -17.198
Positive Control Mitomycin-C 
 0.0E-4    
 50 1048 518 0.494 10.36 26.0 16.143
Mitomycin-C 
 0.005     
 10 210 265 1.262 26.50 26.0 196.519
Trend: -2.683        
Probability: 0.996        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/11/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1047 521 0.498 10.42 26.0 0.000
Test Chemical Sodium chloride 
160         
 50 1046 476 0.455 9.52 26.0 -8.550 
500         
 50 1048 434 0.414 8.68 26.0 -16.778 
1600         
 50 1045 478 0.457 9.56 26.0 -8.078 
5000         
 50 1048 450 0.429 9.00 26.0 -13.710
Positive Control Cyclophosphamide 
 0.3       
 50 1046 829 0.793 16.58 26.0 59.269
Cyclophosphamide 
 0.6       
 10 208 261 1.255 26.10 26.0 152.166
Trend: -2.039        
Probability: 0.979        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 03/14/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1038 387 0.373 7.74 26.0 0.000
Test Chemical Sodium chloride 
2000         
 50 1040 426 0.410 8.52 26.0 9.866 
3000         
 50 1041 441 0.424 8.82 26.0 13.625 
4000         
 50 1040 448 0.431 8.96 26.0 15.540 
5000         
 50 1037 432 0.417 8.64 26.0 11.736
Positive Control Cyclophosphamide 
 0.2       
 50 1049 749 0.714 14.98 26.0 91.511
Cyclophosphamide 
 0.6       
 10 209 242 1.158 24.20 26.0 210.567
Trend: 1.823        
Probability: 0.034