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Study Information
Study Attribute Value
CEBS Accession Number: 002-02814-0002-0000-9
Chemical Name: Sodium chloride
CASRN: 7647-14-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 118875_CA
Study Result: Equivocal

Study Result: Equivocal
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Questionable 
No Activation  2  Negative 

Trial #:1   Activation: No Activation    Date: 04/10/1985    Harvest Time: 14.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Sodium chloride 
1600         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
3000         
 100 4 0.040 3.0 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 
4000         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
5000         
 200 7 0.035 3.5 3 0.015 1.5 4 0.020 2.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.125     
 100 25 0.250 19.0 18 0.180 15.0 7 0.070 6.0 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 19 0.380 30.0 12 0.240 20.0 7 0.140 14.0 0 0.000 0.0
Trend: 1.611 1.405 0.911  
Probability: 0.054 0.080 0.181  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 01/28/1985    Harvest Time: 13 hour(s)   Trial Call: Questionable   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Sodium chloride 
160         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
500         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
1600         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 
5000         
 100 5 0.050 5.0 4 0.040 4.0 1 0.010 1.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 78 0.780 47.0 41 0.410 31.0 26 0.260 24.0 11 0.110 2.0
Trend: 2.373 2.268 0.821  
Probability: 0.009 0.012 0.206  


Trial #:2   Activation: No Activation    Date: 01/28/1985    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Sodium chloride 
160         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0 
500         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
1600         
 100 3 0.030 2.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0 
5000         
 200 14 0.070 7.0 5 0.025 2.0 9 0.045 4.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.125     
 100 18 0.180 18.0 11 0.110 11.0 7 0.070 7.0 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 16 0.320 30.0 11 0.220 20.0 5 0.100 10.0 0 0.000 0.0
Trend: 1.760 0.320 1.513  
Probability: 0.039 0.375 0.065