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Study Information
Study Attribute Value
CEBS Accession Number: 002-02814-0003-0000-0
Chemical Name: Sodium chloride
CASRN: 7647-14-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 806416_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 10/16/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1015 348 0.343 6.96 25.5 0.000
Test Chemical Sodium chloride 
300         
 50 1024 389 0.380 7.78 25.5 10.799 
1000         
 50 1029 362 0.352 7.24 25.5 2.608 
3000         
 50 1033 371 0.359 7.42 25.5 4.752
Positive Control Mitomycin-C 
 0.001     
 50 1034 558 0.540 11.16 25.5 57.398
Mitomycin-C 
 0.01      
 5 103 208 2.019 41.60 25.5 488.997
Trend: 0.235        
Probability: 0.407        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/16/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1036 398 0.384 7.96 25.5 0.000
Test Chemical Sodium chloride 
300         
 50 1034 386 0.373 7.72 25.5 -2.827 
1000         
 50 1036 422 0.407 8.44 25.5 6.030 
3000         
 50 1035 435 0.420 8.70 25.5 9.402
Positive Control Cyclophosphamide 
 0.4       
 50 1040 578 0.556 11.56 25.5 44.668
Cyclophosphamide 
2         
 5 105 162 1.543 32.40 25.5 301.608
Trend: 1.631        
Probability: 0.051