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Study Information
Study Attribute Value
CEBS Accession Number: 002-02820-0001-0000-5
Chemical Name: Sodium diethyldithiocarbamate
CASRN: 148-18-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 552900_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
No Activation  2  Weakly Positive 
No Activation  3  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 01/25/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1050 326 0.310 6.52 26.5 0.000
Test Chemical Sodium diethyldithiocarbamate 
 0.095     
 50 1045 367 0.351 7.34 30.5 13.115
Positive Control Mitomycin-C 
 0.0015    
 50 1050 496 0.472 9.92 26.5 52.147
Mitomycin-C 
 0.01      
 10 209 308 1.474 30.80 26.5 374.653
Trend: 0.000        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 02/05/1985    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1046 339 0.324 6.78 26.0 0.000
Test Chemical Sodium diethyldithiocarbamate 
 0.05      
 50 1048 384 0.366 7.68 26.0 13.058 
 0.075     
 50 1045 381 0.365 7.62 26.0 12.497 
 0.1       
 50 1045 427 0.409 8.54 30.0 26.079
Positive Control Mitomycin-C 
 0.0015    
 50 1047 610 0.583 12.20 26.0 79.769
Mitomycin-C 
 0.01      
 10 209 323 1.545 32.30 26.0 376.857
Trend: 2.947        
Probability: 0.002        

Trial #: 3    Activation: No Activation    Date: 03/12/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1050 357 0.340 7.14 30.0 0.000
Test Chemical Sodium diethyldithiocarbamate 
 0.075     
 50 1050 405 0.386 8.10 30.0 13.445 
 0.1       
 50 1051 373 0.355 7.46 30.0 4.382 
 0.15      
 50 1046 405 0.387 8.10 30.0 13.879
Positive Control Mitomycin-C 
 0.0015    
 50 1045 514 0.492 10.28 30.0 44.666
Mitomycin-C 
 0.01      
 10 210 260 1.238 26.00 26.0 264.146
Trend: 1.393        
Probability: 0.082        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/25/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1043 383 0.367 7.66 26.0 0.000
Test Chemical Sodium diethyldithiocarbamate 
 0.318     
 50 1046 391 0.374 7.82 26.0 1.796 
 0.954     
 50 1048 382 0.365 7.64 26.0 -0.737 
3.18      
 50 1046 426 0.407 8.52 30.0 10.908
Positive Control Cyclophosphamide 
 0.5       
 50 1050 659 0.628 13.18 26.0 70.916
Cyclophosphamide 
2.5       
 10 211 406 1.924 40.60 26.0 423.997
Trend: 1.324        
Probability: 0.093