Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02820-0002-0000-6 |
Chemical Name: | Sodium diethyldithiocarbamate |
CASRN: | 148-18-5 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 552900_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Sodium diethyldithiocarbamate | 0.1 | 100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
0.3 | 100 | 4 | 0.040 | 4.0 | 0 | 0.000 | 0.0 | 4 | 0.040 | 4.0 | 0 | 0.000 | 0.0 | ||
1 | 100 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 5 | 50 | 92 | 1.840 | 72.0 | 29 | 0.580 | 48.0 | 33 | 0.660 | 46.0 | 30 | 0.600 | 3.0 |
Trend: | -0.992 | 0.000 | -0.992 | ||||||||||||
Probability: | 0.839 | 0.000 | 0.839 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 3 | 0.030 | 2.0 | 0 | 0.000 | 0.0 | 3 | 0.030 | 2.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Sodium diethyldithiocarbamate | 15.2 | 100 | 6 | 0.060 | 6.0 | 1 | 0.010 | 1.0 | 5 | 0.050 | 5.0 | 0 | 0.000 | 0.0 |
50.7 | 100 | 5 | 0.050 | 4.0 | 1 | 0.010 | 1.0 | 4 | 0.040 | 3.0 | 0 | 0.000 | 0.0 | ||
152 | 100 | 4 | 0.040 | 4.0 | 0 | 0.000 | 0.0 | 4 | 0.040 | 4.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 50 | 50 | 37 | 0.740 | 42.0 | 20 | 0.400 | 30.0 | 17 | 0.340 | 24.0 | 0 | 0.000 | 0.0 |
Trend: | 0.454 | 0.015 | 0.479 | ||||||||||||
Probability: | 0.325 | 0.494 | 0.316 |