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Study Information
Study Attribute Value
CEBS Accession Number: 002-02821-0001-0000-6
Chemical Name: Sodium dodecyl sulfate
CASRN: 151-21-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 908384_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
No Activation  2  Negative 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 
Induced Rat Liver S9  3_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 03/27/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1037 442 0.426 8.84 26.5 2.907
Dimethyl Sulfoxide 
0         
 50 1043 432 0.414 8.64 26.5 0.000
Test Chemical Sodium dodecyl sulfate 
1.6       
 50 1039 459 0.442 9.18 26.5 6.659 
5         
 50 1044 469 0.449 9.38 26.5 8.461 
16         
 50 1042 430 0.413 8.60 26.5 -0.367 
50         
 50 1037 465 0.448 9.30 26.5 8.262 
160         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1044 1312 1.257 26.24 26.5 203.413
Mitomycin-C 
 0.01      
 10 210 823 3.919 82.30 26.5 846.196
Trend: 0.606        
Probability: 0.272        

Trial #: 2    Activation: No Activation    Date: 05/08/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1046 430 0.411 8.60 26.0 -1.055
Dimethyl Sulfoxide 
0         
 50 1047 435 0.415 8.70 26.0 0.000
Test Chemical Sodium dodecyl sulfate 
10         
 50 1049 469 0.447 9.38 26.0 7.611 
25         
 50 1045 434 0.415 8.68 26.0 -0.039 
50         
 50 1047 448 0.428 8.96 26.0 2.989 
75         
 50 1040 475 0.457 9.50 26.0 9.930 
100         
 0 0 0 0.000 0.00 31.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1046 1313 1.255 26.26 26.0 202.128
Mitomycin-C 
 0.01      
 10 209 644 3.081 64.40 26.0 641.647
Trend: 0.803        
Probability: 0.211        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/27/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 493 0.470 9.86 26.5 0.000
Negative (Not Specified) 
0         
 50 1038 498 0.480 9.96 26.5 1.987
Test Chemical Sodium dodecyl sulfate 
1.6       
 50 1048 484 0.462 9.68 26.5 -1.826 
5         
 50 1050 476 0.453 9.52 26.5 -3.632 
16         
 50 1037 446 0.430 8.92 26.5 -8.574 
50         
 50 1036 555 0.536 11.10 26.5 13.880 
160         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.3       
 50 1046 658 0.629 13.16 26.5 33.724
Cyclophosphamide 
2         
 10 208 315 1.514 31.50 26.5 221.930
Trend: 1.459        
Probability: 0.072        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 05/08/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1046 449 0.429 8.98 26.0 3.277
Dimethyl Sulfoxide 
0         
 50 1049 436 0.416 8.72 26.0 0.000
Test Chemical Sodium dodecyl sulfate 
5         
 50 1051 437 0.416 8.74 26.0 0.039 
10         
 50 1046 445 0.425 8.90 26.0 2.357 
25         
 50 1043 424 0.407 8.48 26.0 -2.193 
50         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.3       
 50 1050 600 0.571 12.00 26.0 37.484
Cyclophosphamide 
2         
 10 210 326 1.552 32.60 26.0 273.497
Trend: -0.234        
Probability: 0.592        

Trial #: 3_S9    Activation: Induced Rat Liver S9    Date: 06/07/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1041 443 0.426 8.86 26.0 10.876
Dimethyl Sulfoxide 
0         
 50 1050 403 0.384 8.06 26.0 0.000
Test Chemical Sodium dodecyl sulfate 
10         
 50 1046 398 0.380 7.96 26.0 -0.863 
20         
 50 1046 428 0.409 8.56 26.0 6.610 
30         
 50 1044 430 0.412 8.60 26.0 7.313 
40         
 50 1042 425 0.408 8.50 26.0 6.269 
50         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.3       
 50 1041 569 0.547 11.38 26.0 42.412
Cyclophosphamide 
2         
 10 208 362 1.740 36.20 26.0 353.450
Trend: 1.393        
Probability: 0.082