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Study Information
Study Attribute Value
CEBS Accession Number: 002-02821-0002-0000-7
Chemical Name: Sodium dodecyl sulfate
CASRN: 151-21-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 908384_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Negative 

Trial #:1   Activation: No Activation    Date: 04/05/1984    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Sodium dodecyl sulfate 
1.6       
 100 2 0.020 1.0 0 0.000 0.0 2 0.020 1.0 0 0.000 0.0 
5         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 
16         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
50         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.25      
 100 38 0.380 32.0 18 0.180 16.0 20 0.200 18.0 0 0.000 0.0
Mitomycin-C 
1         
 50 39 0.780 38.0 20 0.400 30.0 9 0.180 14.0 10 0.200 1.0
Trend: -0.004 0.813 -0.709  
Probability: 0.501 0.208 0.761  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 06/06/1984    Harvest Time: 12.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Sodium dodecyl sulfate 
5         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
16         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
25         
 100 3 0.030 3.0 2 0.020 2.0 0 0.000 0.0 1 0.010 1.0 
50         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 43 0.430 28.0 28 0.280 20.0 15 0.150 12.0 0 0.000 0.0
Cyclophosphamide 
50         
 50 53 1.060 56.0 41 0.820 50.0 12 0.240 20.0 0 0.000 0.0
Trend: 1.480 1.272 0.121  
Probability: 0.069 0.102 0.452  


Trial #:2   Activation: No Activation    Date: 05/31/1984    Harvest Time: 17.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Sodium dodecyl sulfate 
75         
 100 4 0.040 3.0 1 0.010 1.0 2 0.020 2.0 1 0.010 1.0 
100         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
125         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
150         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.25      
 100 58 0.580 37.0 38 0.380 26.0 20 0.200 17.0 0 0.000 0.0
Mitomycin-C 
1         
 50 41 0.820 52.0 27 0.540 46.0 13 0.260 22.0 1 0.020 1.0
Trend: -1.024 -0.927 -0.514  
Probability: 0.847 0.823 0.696