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Study Information
Study Attribute Value
CEBS Accession Number: 002-02823-0001-0000-8
Chemical Name: Sodium fluoride
CASRN: 7681-49-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 510381_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
No Activation  2  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 01/11/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1049 402 0.383 8.04 26.5 0.000
Test Chemical Sodium fluoride 
1.6       
 50 1047 384 0.367 7.68 26.5 -4.295 
5         
 50 1046 473 0.452 9.46 26.5 17.999 
16         
 50 1048 387 0.369 7.74 26.5 -3.639 
50         
 50 1049 416 0.397 8.32 26.5 3.483 
160         
 0 0 0 0.000 0.00 26.5 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1050 602 0.573 12.04 26.5 49.609
Mitomycin-C 
 0.005     
 10 209 277 1.325 27.70 26.5 245.846
Trend: 0.467        
Probability: 0.320        

Trial #: 2    Activation: No Activation    Date: 03/05/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1046 378 0.361 7.56 26.5 0.000
Test Chemical Sodium fluoride 
5         
 50 1038 360 0.347 7.20 26.5 -4.028 
25         
 50 1048 402 0.384 8.04 26.5 6.146 
50         
 50 1036 415 0.401 8.30 26.5 10.848 
75         
 0 0 0 0.000 0.00 26.5 N/A 
100         
 0 0 0 0.000 0.00 31.5 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1044 592 0.567 11.84 26.5 56.914
Mitomycin-C 
 0.005     
 10 209 288 1.378 28.80 26.5 281.317
Trend: 1.923        
Probability: 0.027        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/11/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1047 521 0.498 10.42 26.0 0.000
Test Chemical Sodium fluoride 
16         
 50 1049 426 0.406 8.52 26.0 -18.390 
50         
 50 1050 444 0.423 8.88 26.0 -15.023 
160         
 50 1050 474 0.451 9.48 26.0 -9.281 
500         
 50 1045 529 0.506 10.58 26.0 1.730 
1600         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.3       
 50 1046 829 0.793 16.58 26.0 59.269
Cyclophosphamide 
 0.6       
 10 208 261 1.255 26.10 26.0 152.166
Trend: 0.945        
Probability: 0.172