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Study Information
Study Attribute Value
CEBS Accession Number: 002-02823-0002-0000-9
Chemical Name: Sodium fluoride
CASRN: 7681-49-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 510381_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Positive 
Induced Rat Liver S9  2_S9  Weakly Positive 
No Activation  3  Negative 

Trial #:1   Activation: No Activation    Date: 03/07/1985    Harvest Time: 13 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Sodium fluoride 
300         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0 
400         
 100 19 0.190 19.0 9 0.090 9.0 10 0.100 10.0 0 0.000 0.0 
500         
 100 39 0.390 39.0 9 0.090 9.0 30 0.300 30.0 0 0.000 0.0 
600         
 100 34 0.340 33.0 11 0.110 11.0 23 0.230 22.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.125     
 100 17 0.170 16.0 10 0.100 9.0 7 0.070 7.0 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 13 0.260 24.0 8 0.160 14.0 5 0.100 10.0 0 0.000 0.0
Trend: 8.403 4.289 6.782  
Probability: 0.000 0.000 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 03/07/1985    Harvest Time: 13 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Sodium fluoride 
400         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0 
600         
 100 3 0.030 3.0 3 0.030 3.0 0 0.000 0.0 0 0.000 0.0 
800         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
1000         
 100 5 0.050 4.0 3 0.030 3.0 2 0.020 2.0 0 0.000 0.0 
1250         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
10         
 100 43 0.430 35.0 26 0.260 25.0 17 0.170 15.0 0 0.000 0.0
Cyclophosphamide 
15         
 50 55 1.100 52.0 29 0.580 42.0 6 0.120 12.0 20 0.400 2.0
Trend: 1.406 1.336 1.067  
Probability: 0.080 0.091 0.143  


Trial #:2   Activation: No Activation    Date: 03/07/1985    Harvest Time: 13 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Sodium fluoride 
300         
 100 3 0.030 2.0 0 0.000 0.0 3 0.030 2.0 0 0.000 0.0 
400         
 100 23 0.230 21.0 0 0.000 0.0 23 0.230 21.0 0 0.000 0.0 
500         
 100 19 0.190 16.0 4 0.040 2.0 15 0.150 15.0 0 0.000 0.0 
600         
 100 27 0.270 27.0 1 0.010 1.0 26 0.260 26.0 0 0.000 0.0 
800         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.125     
 100 17 0.170 16.0 10 0.100 9.0 7 0.070 7.0 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 13 0.260 24.0 8 0.160 14.0 5 0.100 10.0 0 0.000 0.0
Trend: 6.427 1.653 6.233  
Probability: 0.000 0.049 0.000  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 01/28/1985    Harvest Time: 13 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Sodium fluoride 
50         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
160         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
500         
 100 9 0.090 8.0 3 0.030 3.0 5 0.050 4.0 1 0.010 1.0 
1000         
 100 6 0.060 2.0 4 0.040 1.0 2 0.020 2.0 0 0.000 0.0 
1500         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 78 0.780 47.0 41 0.410 31.0 26 0.260 24.0 11 0.110 2.0
Trend: 2.594 1.917 1.972  
Probability: 0.005 0.028 0.024  


Trial #:3   Activation: No Activation    Date: 01/28/1985    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Sodium fluoride 
16         
 100 3 0.030 1.0 0 0.000 0.0 3 0.030 1.0 0 0.000 0.0 
50         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
160         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
500         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0 
1000         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.125     
 100 18 0.180 18.0 11 0.110 11.0 7 0.070 7.0 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 16 0.320 30.0 11 0.220 20.0 5 0.100 10.0 0 0.000 0.0
Trend: 0.029 -1.614 1.180  
Probability: 0.489 0.947 0.119