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Study Information
Study Attribute Value
CEBS Accession Number: 002-02823-0003-0000-0
Chemical Name: Sodium fluoride
CASRN: 7681-49-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 665475_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Weakly Positive 
Induced Rat Liver S9  1_S9  Questionable 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 06/07/1983    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1032 423 0.410 8.46 26.8 0.000
Test Chemical Sodium fluoride 
6.7       
 50 1012 379 0.375 7.58 26.8 -8.631 
20         
 50 1032 413 0.400 8.26 26.8 -2.364 
66.7       
 50 1035 523 0.505 10.46 31.3 23.282 
200         
 0 0 0 0.000 0.00 31.3 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1034 560 0.542 11.20 26.8 32.132
Mitomycin-C 
 0.01      
 5 100 172 1.720 34.40 26.8 319.631
Trend: 3.495        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 06/14/1983    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1039 462 0.445 9.24 26.0 0.000
Negative (Not Specified) 
0         
 0 0 0 0.000 0.00 0.0 N/A
Test Chemical Sodium fluoride 
50         
 50 1021 534 0.523 10.68 26.0 17.622 
75         
 50 1037 565 0.545 11.30 26.0 22.530 
100.5       
 50 1024 532 0.520 10.64 32.5 16.838 
125         
 0 0 0 0.000 0.00 32.5 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1030 588 0.571 11.76 26.0 28.385
Mitomycin-C 
 0.01      
 5 104 262 2.519 52.40 26.0 466.554
Trend: 2.508        
Probability: 0.006        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/14/1983    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1037 476 0.459 9.52 26.0 0.000
Test Chemical Sodium fluoride 
330         
 50 1035 515 0.498 10.30 26.0 8.402 
350         
 50 1032 495 0.480 9.90 26.0 4.495 
400         
 50 1027 559 0.544 11.18 26.0 18.580
Positive Control Cyclophosphamide 
 0.3       
 50 1022 665 0.651 13.30 26.0 41.756
Cyclophosphamide 
2         
 5 105 222 2.114 44.40 26.0 360.612
Trend: 2.623        
Probability: 0.004        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 06/28/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1035 448 0.433 8.96 25.6 0.000
Test Chemical Sodium fluoride 
1200         
 50 1030 579 0.562 11.58 25.6 29.868 
1400         
 50 1020 577 0.566 11.54 30.7 30.689 
1600         
 50 1020 587 0.575 11.74 30.7 32.954
Positive Control Cyclophosphamide 
 0.3       
 50 1034 673 0.651 13.46 25.6 50.368
Cyclophosphamide 
2         
 5 107 226 2.112 45.20 25.6 387.963
Trend: 4.256        
Probability: 0.000