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Study Information
Study Attribute Value
CEBS Accession Number: 002-02823-0015-0000-3
Chemical Name: Sodium fluoride
CASRN: 7681-49-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 855441
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 73 111 60 27 29
    72 94 55 26
    87 104 81 31
    71 90 72 34
Test Chemical Sodium fluoride 
200         
 104 90 94 30 32
    67 73 67 34
   
  
300         
 89 81 90 34 53*
    76 63 146 64
    91 72 164 60
  
400         
 77 49 108 47 45*
    79 37 99 42
    80# 37 116 48
  
500         
 76 14 117 51 55*
    68# 14 101 50
    81 22 157 65
  
600         
 76 11 199 88 83*
    83 9 193 78
  
800         
   
   
Positive Control Methyl Methane Sulfonate 
5         
 68 62 482 237 244*
    62 70 417 226
    70 80 568 270

Nonactivation Trial: 2 Experiment Call: Equivocal
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 118 114 82 23 25
    88# 83 75 28
    111 103 74 22
    120r 131 92 25
Test Chemical Sodium fluoride 
50         
 93 90 77 28 22
    102 86 54 18
    78# 83 46 20
  
100         
 88 63 72 27 27
    96 80 79 27
  
200         
 88 61 61 23 27
    80 57 62 26
    96 53 95 33
  
300         
 109 53 67 21 22
    75 42 41 18
    84 53 67 27
  
400         
 116 40 137 40 36
    92 40 87 31
    131r 59 108 27
  
500         
 97 13 166 57 41*
    106 23 123 39
    80 16 68 28
  
600         
   
   
Positive Control Methyl Methane Sulfonate 
5         
 97 68 298 102 140*
    86 59 271 105
    59 57 378 213

Induced S9 Trial: 1 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 111 118 81 24 26
    108 90 104 32
    105# 89 73 23
    106 103 77 24
Test Chemical Sodium fluoride 
100         
 85 75 66 26
  
200         
 114 79 40 12 21
    98 62 71 24
    87 71 68 26
  
300         
 129r 68 86 22 39
    100# 61 105 35
    89 43 116 44
  
400         
 111 46 109 33 39*
    116 39 105 30
    93 39 149 54
  
500         
 90# 13 203 75 81*
    68 7 240 117
    59 20 90 51
Positive Control 3-Methylcholanthrene 
2.5       
 51 25 534 349 335*
    67 27 629 311
    66 32 682 344

Induced S9 Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 85 74 97 38 33
    82 118 73 30
    74 104 61 28
    88# 104 95 36
Test Chemical Sodium fluoride 
50         
 78 115 59 25 27
    83# 89 72 29
    73 96 60 27
  
100         
 71 97 70 33 38
    91 117 80 29
    76 46 116 51
  
200         
 111 96 135 40 38
    69# 78 83 40
    75 76 76 34
  
300         
 76 48 103 45 52*
    76 56 142 62
    77 45 112 48
  
400         
 70 27 132 63 62*
    83 28 165 66
    79 31 137 58
  
500         
 72 17 223 103 76*
    70 19 146 69
    81 27 134 55
  
600         
   
   
Positive Control 3-Methylcholanthrene 
2.5       
 46 22 777 563 513*
    44 16 703 531
    53# 25 715 447

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination