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Study Information
Study Attribute Value
CEBS Accession Number: 002-02823-0016-0000-4
Chemical Name: Sodium fluoride
CASRN: 7681-49-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 932658
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
  Conc.
uL/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Fischer Medium 
 0         
 59 110 109 61 58
    54# 86 136.5 84
    67# 124 82 41
    55 80 76 46
Test Chemical Sodium fluoride 
62.5       
 58 101 162 93 105*
    47 76 162 116
  
125         
 61# 82 120 66 97*
    44 74 168 129
  
250         
 63 79 139 74 73
    55 61 121 73
  
500         
 85# 35 143 56 83
    55# 37 180 109
  
1000         
 36# 5 169 159 134*
    44 11 142 109
Positive Control Methyl Methane Sulfonate 
15         
 18 15 175 318 343*
    15 11 169 367

Nonactivation Trial: 2 Experiment Call: Positive
  Conc.
uL/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Fischer Medium 
 0         
 80 99 57 24 26
    89# 101 74 28
Test Chemical Sodium fluoride 
600         
 78 56 44 19 22
    66 44 50 25
  
700         
 60 40 51 29 23
    71 40 38 18
  
800         
 68 34 72 35 34
    102 25 103 34
  
900         
 63 20 115 61 64*
    55 14 109 66
  
1000         
 76 12 273 120 95*
    89 17 185 69
Positive Control Methyl Methane Sulfonate 
15         
 51 40 132 86 86*

Nonactivation Trial: 3 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Fischer Medium 
 0         
 91 113 136 50 51
    76 99 135 59
    91 101 110 40
    104 87 172 55
Test Chemical Sodium fluoride 
500         
 85 33 165 64 59
    79 33 125 53
  
600         
 97 25 148 51 58
    77 31 149 65
  
700         
 94 25 152 54 66
    87 25 202 78
  
800         
 79 21 238 101 92*
    78 19 193 82
  
900         
 80 14 467 194 190*
    76 12 423 187
  
1000         
   
Positive Control Methyl Methane Sulfonate 
15         
 56 34 91 54 49
    48 36 63 44

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination