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Study Information
Study Attribute Value
CEBS Accession Number: 002-02823-0017-0000-5
Chemical Name: Sodium fluoride
CASRN: 7681-49-4
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: A12928_CA
Study Result: Negative (Nonstandard Protocol)

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 09/20/91 6 Mouse Male Bone Marrow Dosed-Water x 42/study, 6 weeks 0.1999
Test Group Dose
(ppm)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Cyclophosphamide 
114         
 8 11.25 ± 2.23 0.0000
Test Chemical Sodium fluoride 
100         
 8 3.50 ± 0.50 0.2035
  
200         
 8 3.00 ± 0.53 0.3327
  
400         
 8 3.75 ± 1.62 0.1548
Vehicle Control No Stressor 
 0         
 8 2.50 ± 0.73 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed