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Study Information
Study Attribute Value
CEBS Accession Number: 002-02827-0001-0000-2
Chemical Name: Sodium naphthenate
CASRN: 61790-13-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 058122_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 03/12/1991    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1048 365 0.348 7.30 26.0 0.000
Test Chemical Sodium naphthenate 
17         
 50 1050 392 0.373 7.84 26.0 7.193 
50         
 50 1048 389 0.371 7.78 26.0 6.575 
167         
 50 1050 445 0.424 8.90 26.0 21.686 
500         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1050 514 0.490 10.28 26.0 40.554
Mitomycin-C 
 0.004     
 10 210 203 0.967 20.30 26.0 177.553
Trend: 2.666        
Probability: 0.004        

Trial #: 2    Activation: No Activation    Date: 04/24/1991    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1050 368 0.350 7.36 31.0 6.875
Water 
0         
 50 1049 344 0.328 6.88 26.0 0.000
Test Chemical Sodium naphthenate 
100         
 50 1050 401 0.382 8.02 26.0 16.459 
150         
 50 1044 433 0.415 8.66 26.0 26.475 
200         
 50 1048 484 0.462 9.68 31.0 40.832 
250         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1050 549 0.523 10.98 26.0 59.441
Mitomycin-C 
 0.004     
 10 210 243 1.157 24.30 26.0 252.861
Trend: 4.962        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/12/1991    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1050 412 0.392 8.24 31.0 4.105
Water 
0         
 50 1048 395 0.377 7.90 26.0 0.000
Test Chemical Sodium naphthenate 
17         
 50 1048 396 0.378 7.92 26.0 0.253 
50         
 50 1050 413 0.393 8.26 26.0 4.358 
167         
 50 1049 478 0.456 9.56 31.0 20.897 
500         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.125     
 50 1050 479 0.456 9.58 26.0 21.035
Cyclophosphamide 
 0.5       
 10 210 199 0.948 19.90 26.0 151.419
Trend: 2.909        
Probability: 0.002