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Study Information
Study Attribute Value
CEBS Accession Number: 002-02835-0001-0000-1
Chemical Name: Sodium xylenesulfonate
CASRN: 1300-72-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 344381_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 05/20/1986    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1029 392 0.381 7.84 25.5 0.000
Test Chemical Sodium xylenesulfonate 
500         
 50 1041 436 0.419 8.72 25.5 9.942 
1666.7       
 50 1012 432 0.427 8.64 25.5 12.055 
5000         
 50 1023 528 0.516 10.56 30.7 35.484
Positive Control Mitomycin-C 
 0.001     
 50 1036 556 0.537 11.12 25.5 40.878
Mitomycin-C 
 0.01      
 5 105 192 1.829 38.40 25.5 380.000
Trend: 4.460        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 06/03/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 25 512 172 0.336 6.88 25.5 0.000
Test Chemical Sodium xylenesulfonate 
2513         
 25 517 225 0.435 9.00 32.5 29.549 
3750         
 25 513 241 0.470 9.64 32.5 39.843 
5000         
 25 521 265 0.509 10.60 32.5 51.408
Positive Control Mitomycin-C 
 0.001     
 25 506 295 0.583 11.80 25.5 73.545
Mitomycin-C 
 0.01      
 5 103 195 1.893 39.00 25.5 463.558
Trend: 4.242        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 05/20/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1034 392 0.379 7.84 25.5 0.000
Test Chemical Sodium xylenesulfonate 
500         
 50 1039 413 0.397 8.26 25.5 4.850 
1666.7       
 50 1036 391 0.377 7.82 25.5 -0.448 
5000         
 50 1032 396 0.384 7.92 25.5 1.216
Positive Control Cyclophosphamide 
 0.4       
 50 1039 631 0.607 12.62 25.5 60.195
Cyclophosphamide 
2         
 5 103 169 1.641 33.80 25.5 332.797
Trend: -0.080        
Probability: 0.532