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Study Information
Study Attribute Value
CEBS Accession Number: 002-02835-0002-0000-2
Chemical Name: Sodium xylenesulfonate
CASRN: 1300-72-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 344381_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 06/12/1986    Harvest Time: 20 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 3 0.015 1.5 2 0.010 1.0 1 0.005 0.5 0 0.000 0.0
Negative (Not Specified) 
0         
 200 3 0.015 1.0 0 0.000 0.0 3 0.015 1.0 0 0.000 0.0
Test Chemical: Sodium xylenesulfonate 
2513         
 200 7 0.035 3.0 0 0.000 0.0 7 0.035 3.0 0 0.000 0.0 
3750         
 200 8 0.040 3.5 1 0.005 0.5 7 0.035 3.0 0 0.000 0.0 
5000         
 200 6 0.030 3.0 0 0.000 0.0 6 0.030 3.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 200 56 0.280 20.5 13 0.065 6.0 43 0.215 16.5 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 23 0.920 48.0 6 0.240 24.0 17 0.680 40.0 0 0.000 0.0
Trend: 1.318 0.547 1.226  
Probability: 0.094 0.292 0.110  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 06/12/1986    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 8 0.040 3.5 4 0.020 2.0 4 0.020 1.5 0 0.000 0.0
Negative (Not Specified) 
0         
 200 7 0.035 3.5 4 0.020 2.0 3 0.015 1.5 0 0.000 0.0
Test Chemical: Sodium xylenesulfonate 
2513         
 200 9 0.045 4.5 4 0.020 2.0 5 0.025 2.5 0 0.000 0.0 
3750         
 200 8 0.040 3.0 2 0.010 1.0 6 0.030 2.0 0 0.000 0.0 
5000         
 200 8 0.040 3.5 0 0.000 0.0 7 0.035 3.0 1 0.005 0.5
Positive Control: Cyclophosphamide 
7.5       
 200 40 0.200 16.0 10 0.050 5.0 30 0.150 11.5 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 21 0.840 48.0 4 0.160 12.0 17 0.680 44.0 0 0.000 0.0
Trend: -0.283 -1.980 0.821  
Probability: 0.612 0.976 0.206