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Study Information
Study Attribute Value
CEBS Accession Number: 002-02837-0001-0000-3
Chemical Name: Stannous chloride
CASRN: 7772-99-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 421347_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
No Activation  2  Positive 
No Activation  3  Positive 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 04/09/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 430 0.411 8.60 26.5 0.000
Test Chemical Stannous chloride 
1.6       
 50 1043 436 0.418 8.72 26.5 1.687 
5         
 50 1047 413 0.394 8.26 26.5 -4.045 
16         
 50 1049 456 0.435 9.12 26.5 5.743 
50         
 50 1051 469 0.446 9.38 26.5 8.551 
160         
 0 0 0 0.000 0.00 26.5 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1048 584 0.557 11.68 26.5 35.555
Mitomycin-C 
 0.005     
 10 210 191 0.910 19.10 26.5 121.247
Trend: 1.377        
Probability: 0.084        

Trial #: 2    Activation: No Activation    Date: 05/06/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1039 446 0.429 8.92 26.5 0.000
Test Chemical Stannous chloride 
75         
 50 1044 606 0.580 12.12 31.0 35.224 
100         
 50 1042 668 0.641 13.36 35.5 49.345 
125         
 50 1032 697 0.675 13.94 35.5 57.338 
150         
 50 1048 718 0.685 14.36 35.5 59.604
Positive Control Mitomycin-C 
 0.001     
 50 1046 624 0.597 12.48 26.5 38.974
Mitomycin-C 
 0.005     
 10 210 235 1.119 23.50 26.5 160.693
Trend: 8.102        
Probability: 0.000        

Trial #: 3    Activation: No Activation    Date: 08/14/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 465 0.444 9.30 26.0 0.000
Test Chemical Stannous chloride 
25         
 50 1049 584 0.557 11.68 31.0 25.472 
50         
 50 1051 571 0.543 11.42 31.0 22.445 
75         
 50 1047 622 0.594 12.44 36.0 33.891 
100         
 50 1052 663 0.630 13.26 36.0 42.039 
125         
 0 0 0 0.000 0.00 36.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1049 591 0.563 11.82 26.0 26.976
Mitomycin-C 
 0.005     
 10 210 285 1.357 28.50 26.0 205.868
Trend: 5.473        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/09/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1043 435 0.417 8.70 26.5 0.000
Test Chemical Stannous chloride 
16         
 50 1047 417 0.398 8.34 26.5 -4.504 
50         
 50 1048 457 0.436 9.14 26.5 4.556 
160         
 50 1048 459 0.438 9.18 26.5 5.014 
500         
 50 1043 494 0.474 9.88 26.5 13.563 
1600         
 0 0 0 0.000 0.00 26.5 N/A
Positive Control Cyclophosphamide 
 0.3       
 50 1048 839 0.801 16.78 26.5 91.953
Cyclophosphamide 
 0.6       
 10 208 277 1.332 27.70 26.5 219.309
Trend: 2.372        
Probability: 0.009        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 05/06/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 423 0.404 8.46 26.0 0.000
Test Chemical Stannous chloride 
160         
 50 1050 474 0.451 9.48 26.0 11.843 
500         
 50 1046 490 0.468 9.80 26.0 16.061 
750         
 50 1046 646 0.618 12.92 31.0 53.011 
1000         
 29 604 344 0.570 11.86 31.0 41.105 
1250         
 0 0 0 0.000 0.00 31.0 N/A
Positive Control Cyclophosphamide 
 0.2       
 50 1048 923 0.881 18.46 26.0 118.203
Cyclophosphamide 
 0.6       
 10 211 299 1.417 29.90 26.0 251.083
Trend: 6.821        
Probability: 0.000